Unified and contrasting graphical Lasso for brain network discovery

Xinyue Liu, Xiangnan Kong, Ann B. Ragin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

The analysis of brain imaging data has attracted much attention recently. A popular analysis is to discover a network representation of brain from the neuroimaging data, where each node denotes a brain region and each edge represents a functional association or structural connection between two brain regions. Motivated by the multi-subject and multi-collection settings in neuroimaging studies, in this paper, we consider brain network discovery under two novel settings: 1) unified setting: Given a collection of subjects, discover a single network that is good for all subjects. 2) contrasting setting: Given two collections of subjects, discover a single network that best discriminates two collections. We show that the existing formulation of graphical Lasso (GLasso) cannot address above problems properly. Two novel models, UGLasso (Unified Graphical Lasso) and CGLasso(Contrasting Graphical Lasso), are proposed to address these two problems respectively. We evaluate our methods on synthetic data and two realworld functional magnetic resonance imaging (fMRI) datasets. Empirical results demonstrate the effectiveness of the proposed methods.

Original languageEnglish (US)
Title of host publicationProceedings of the 17th SIAM International Conference on Data Mining, SDM 2017
EditorsNitesh Chawla, Wei Wang
PublisherSociety for Industrial and Applied Mathematics Publications
Pages180-188
Number of pages9
ISBN (Electronic)9781611974874
DOIs
StatePublished - 2017
Event17th SIAM International Conference on Data Mining, SDM 2017 - Houston, United States
Duration: Apr 27 2017Apr 29 2017

Publication series

NameProceedings of the 17th SIAM International Conference on Data Mining, SDM 2017

Other

Other17th SIAM International Conference on Data Mining, SDM 2017
Country/TerritoryUnited States
CityHouston
Period4/27/174/29/17

ASJC Scopus subject areas

  • Software
  • Computer Science Applications

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