Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial

Todd J. Farchione*, Christopher P. Fairholme, Kristen K. Ellard, Christina Lynn Boisseau, Johanna Thompson-Hollands, Jenna R. Carl, Matthew W. Gallagher, David H. Barlow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

435 Scopus citations


This study further evaluates the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). A diagnostically heterogeneous clinical sample of 37 patients with a principal anxiety disorder diagnosis was enrolled in a randomized controlled trial (RCT) involving up to 18 sessions of treatment and a 6-month follow-up period. Patients were randomly assigned to receive either immediate treatment with the UP (n=26) or delayed treatment, following a 16-week wait-list control period (WLC; n=11). The UP resulted in significant improvement on measures of clinical severity, general symptoms of depression and anxiety, levels of negative and positive affect, and a measure of symptom interference in daily functioning across diagnoses. In comparison, participants in the WLC condition exhibited little to no change following the 16-week wait-list period. The effects of UP treatment were maintained over the 6-month follow-up period. Results from this RCT provide additional evidence for the efficacy of the UP in the treatment of anxiety and comorbid depressive disorders, and provide additional support for a transdiagnostic approach to the treatment of emotional disorders.

Original languageEnglish (US)
Pages (from-to)666-678
Number of pages13
JournalBehavior Therapy
Issue number3
StatePublished - Sep 2012


  • Anxiety disorders
  • Cognitive-behavioral treatment
  • Transdiagnostic
  • Unified protocol

ASJC Scopus subject areas

  • Clinical Psychology


Dive into the research topics of 'Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial'. Together they form a unique fingerprint.

Cite this