Uniform data set language measures for bvftd and ppa diagnosis and monitoring

Adam M. Staffaroni*, Sandra Weintraub, Katya Rascovsky, Katherine P. Rankin, Jack Taylor, Julie A. Fields, Kaitlin B. Casaletto, Argye E. Hillis, Sladjana Lukic, Maria Luisa Gorno-Tempini, Hilary Heuer, Merilee A. Teylan, Walter A. Kukull, Bruce L. Miller, Bradley F. Boeve, Howard J. Rosen, Adam L. Boxer, Joel H. Kramer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Introduction: The Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential diagnosis and disease monitoring. Methods: Linear regressions compared baseline performances in 1655 National Alzheimer’s Coordinating Center participants (behavioral variant frontotemporal dementia (bvFTD, n = 612), semantic variant primary progressive aphasia (svPPA, n = 185), non-fluent/agrammatic variant PPA (nfvPPA, n = 168), logopenic variant PPA (lvPPA, n = 109), and controls (n = 581)). Sample sizes to detect treatment effects were estimated using longitudinal data. Results: Among PPAs, the FTLD-MOD language tasks and UDS Multilingual Naming Test accurately discriminated svPPA. Number Span Forward best discriminated lvPPA; Phonemic:Semantic Fluency ratio was excellent for nfvPPA classification. UDS fluency and naming measures required the smallest sample size to detect meaningful change. Discussion: The FTLD-MOD and UDS differentiated among PPA subtypes. UDS 3.0 measures performed best for longitudinal monitoring.

Original languageEnglish (US)
Article numbere12148
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume13
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Clinical trials
  • Cognition
  • Differential diagnosis
  • Endpoints
  • FTLD module
  • Frontotemporal dementia (FTD)
  • Longitudinal
  • Neuropsychology
  • Primary progressive aphasia (PPA)
  • Speech

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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