Unique Challenges of Hepatitis C in Infants, Children, and Adolescents

Claudia Espinosa*, Ravi Jhaveri, A. Sidney Barritt

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Purpose: Hepatitis C, a chronic disease with deadly consequences, is no longer predominantly a disease of older people. Methods: A limited search was conducted of the relevant literature on 2 topics: (1) the impact of hepatitis C on infants exposed by vertical transmission; and (2) the impact of hepatitis C infection on infected children and adolescents. The findings were supplemented by the first-hand experience of the authors. Findings: Young people, including women of childbearing age, infants, children, and adolescents, are being especially affected by hepatitis C infection secondary to the intravenous drug use and opioid epidemic. Unfortunately, estimates of disease in young populations are all misleading because universal screening has not been implemented. Implications: Lack of implementation of policies for screening and therapy on most affected populations will be responsible for perpetuation of this infection. In the era of highly effective therapy and a regimen that is approved by the US Food and Drug Administration for children, this outcome is unacceptable.

Original languageEnglish (US)
Pages (from-to)1299-1307
Number of pages9
JournalClinical Therapeutics
Issue number8
StatePublished - Aug 1 2018


  • DAAs
  • direct-acting antiviral
  • HCV
  • hepatitis C virus
  • mother-to-child transmission
  • MTCT

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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