Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease

Tarek Magdy; Paul W. Burridge

doi:10.1016/j.stem.2019.01.008

Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease

Tarek Magdy, Paul W. Burridge^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.

Original language	English (US)
Pages (from-to)	203-205
Number of pages	3
Journal	Cell stem cell
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.stem.2019.01.008
State	Published - Feb 7 2019

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2019.01.008

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title = "Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease",

abstract = "Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.",

author = "Tarek Magdy and Burridge, {Paul W.}",

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AU - Burridge, Paul W.

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Y1 - 2019/2/7

N2 - Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.

AB - Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.

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Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease

Abstract

ASJC Scopus subject areas

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