Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease

Tarek Magdy, Paul Burridge

Research output: Contribution to journalShort survey

Abstract

Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.

Original languageEnglish (US)
Pages (from-to)203-205
Number of pages3
JournalCell Stem Cell
Volume24
Issue number2
DOIs
StatePublished - Feb 7 2019

Fingerprint

Coronary Artery Disease
Genotype
Phenotype
Induced Pluripotent Stem Cells
Intergenic DNA
Genome-Wide Association Study
Gene Editing

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

Cite this

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abstract = "Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.",
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Unraveling Difficult Answers : From Genotype to Phenotype in Coronary Artery Disease. / Magdy, Tarek; Burridge, Paul.

In: Cell Stem Cell, Vol. 24, No. 2, 07.02.2019, p. 203-205.

Research output: Contribution to journalShort survey

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