Unraveling the biological roles of reactive oxygen species

Michael P. Murphy, Arne Holmgren, Nils Göran Larsson, Barry Halliwell, Christopher J. Chang, Balaraman Kalyanaraman, Sue Goo Rhee, Paul J. Thornalley, Linda Partridge, David Gems, Thomas Nyström, Vsevolod Belousov, Paul T. Schumacker, Christine C. Winterbourn

Research output: Contribution to journalReview articlepeer-review

642 Scopus citations


Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalCell Metabolism
Issue number4
StatePublished - Apr 6 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Physiology
  • Cell Biology


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