TY - JOUR
T1 - Unrelated patients with discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) share the major histocompatibility complex (MHC) markers. Report of two Mexican families
AU - Garcia-Gonzalez, E.
AU - Melin-Aldana, H.
AU - Vargas-Alarcon, G.
AU - Vega-Memije, E.
AU - Alcocer-Varela, J.
AU - Alarcon-Segovia, S.
AU - Granados, J.
PY - 1995
Y1 - 1995
N2 - Lupus erythematosus is a polymorphic disease that has been known since the last century. Several cases of systemic lupus erythematosus (SLE) can occur in a family, but the association of SLE and discoid lupus erythematosus (DLE) in family members is infrequent. Here, we report on two, unrelated Mexican families each one With some members having SLE and several others with DLE. All five patients shared the MHC haplotype: (HLA-A1, B8, Cw7, DR3, DQ2, DRw52, SC01, BF*S, C2*C, C4A*0, C4B*1) suggesting that common genetic mechanisms are responsible of these findings.
AB - Lupus erythematosus is a polymorphic disease that has been known since the last century. Several cases of systemic lupus erythematosus (SLE) can occur in a family, but the association of SLE and discoid lupus erythematosus (DLE) in family members is infrequent. Here, we report on two, unrelated Mexican families each one With some members having SLE and several others with DLE. All five patients shared the MHC haplotype: (HLA-A1, B8, Cw7, DR3, DQ2, DRw52, SC01, BF*S, C2*C, C4A*0, C4B*1) suggesting that common genetic mechanisms are responsible of these findings.
KW - DLE and SLE in family members
KW - Discoid lupus erythematosus (DLE)
KW - Haplotype sharing between SLE and DLE
KW - Major histocompatibility complex (MHC)
KW - Systemic lupus erythematosus (SLE)
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M3 - Article
AN - SCOPUS:0028829401
SN - 1167-1122
VL - 5
SP - 572
EP - 574
JO - European Journal of Dermatology
JF - European Journal of Dermatology
IS - 7
ER -