Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

Jason M.D. Kalapothakis; Yana Berezovskaya; Cleidiane G. Zampronio; Peter A. Faull; Perdita E. Barran; Helen J. Cooper

doi:10.1039/c3cc46356g

Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

Jason M.D. Kalapothakis, Yana Berezovskaya, Cleidiane G. Zampronio, Peter A. Faull, Perdita E. Barran^*, Helen J. Cooper

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The helix-forming character of a model decapeptide, L₄PL₄K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics.

Original language	English (US)
Pages (from-to)	198-200
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	2
DOIs	https://doi.org/10.1039/c3cc46356g
State	Published - Nov 28 2014
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "The helix-forming character of a model decapeptide, L4PL4K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics.",

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AU - Kalapothakis, Jason M.D.

AU - Berezovskaya, Yana

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AU - Faull, Peter A.

AU - Barran, Perdita E.

AU - Cooper, Helen J.

PY - 2014/11/28

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AB - The helix-forming character of a model decapeptide, L4PL4K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics.

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Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

Abstract

ASJC Scopus subject areas

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