Unusual presentations of BK virus infections in pediatric renal transplant recipients

Keri A. Drake*, Lydia Najera, Robyn C. Reed, Priya S. Verghese

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

BKV has emerged as a significant pathogen in the field of transplantation, predominantly causing BKV nephropathy in renal transplant recipients and hemorrhagic cystitis in HSCT recipients. However, case reports describe more diverse complications, and we too present three unusual cases of BKV infections in pediatric renal transplant recipients. First, we describe a case of biopsy-proven renal damage secondary to BKV prior to the onset of viremia, demonstrating that BKV nephropathy can occur without preceding viremia. We also present two renal transplant recipients with persistent BK viruria, one with BKV-associated hemorrhagic cystitis and the other with microscopic hematuria. Therefore, we conclude that BKV manifestations may be more diverse than previously thought and suggest clinical utility in urine BKV qPCR testing in specific transplant recipients.

Original languageEnglish (US)
Pages (from-to)E9-E15
JournalPediatric transplantation
Volume17
Issue number1
DOIs
StatePublished - Feb 1 2013

Keywords

  • BK virus
  • BKV nephropathy
  • hemorrhagic cystitis
  • renal transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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