Unusual primary ocular neoplasm in a child: Leiomyosarcoma of the ciliary body

Mariana M. Cajaiba, Martha M. Chojniak, Isabela W. Cunha

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Primary uveal-tract neoplasms are extremely rare in childhood; the most common lesions found are melanocytic. We report here the case of a 7-year-old girl who underwent enucleation of the right eye with clinical suspicion of choroid melanoma as a result of a ciliary body mass that extended to the posterior chamber. Histologically, the neoplasm featured spindle cell morphology, atypia, and mitoses. The tumor expressed smooth muscle a actin, panactin HHF-35, and desmin, whereas immunohistochemistry for melanocytic markers, such as S-100, Melan-A, and HMB-45, was negative. Based on these features, the diagnosis of leiomyosarcoma of the ciliary body was firmly established. Although several leiomyomas have been reported in the literature, there are only 2 previously reported cases of primary leiomyosarcoma of the uveal tract. Immunohistochemical expression of muscle proteins allowed distinction from the most common melanocytic tumors arising in this location.

Original languageEnglish (US)
Pages (from-to)479-481
Number of pages3
JournalPediatric and Developmental Pathology
Volume11
Issue number6
DOIs
StatePublished - Nov 1 2008

Keywords

  • Ciliary body
  • Immunohistochemistry
  • Leiomyosarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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