Unusual Serous Retinal Detachment in a Patient with Waldenstrom Macroglobulinemia: A Case Report

Albert B. Lin, Alan T. Sheyman, Lee M. Jampol*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background/Purpose: To report an unusual appearance of severe bilateral serous detachments in a patient with Waldenstrom macroglobulinemia. Methods: A case report of a Fifty-six-year-old female patient with Waldenstrom macroglobulinemia. Results: A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom. The patient's IgM levels remained abnormally elevated in the initial stages of her disease course, leading to dramatic ocular findings and images on optical coherence tomography. Chemotherapy was initiated and IgM levels slowly declined, with some improvement in macular fluid as IgM normalized. Conclusion: Waldenstrom macroglobulinemia may lead to dramatic retinal pathology if IgM levels remain elevated. Prompt chemotherapy and reduction of immunoglobulin levels should be undertaken to preserve retinal architecture.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalRetinal Cases and Brief Reports
Volume13
Issue number1
DOIs
StatePublished - Dec 1 2019

Keywords

  • Waldenstrom macroglobulinemia
  • maculopathy
  • retinal detachment
  • serous macular detachment

ASJC Scopus subject areas

  • Ophthalmology

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