Unusual Serous Retinal Detachment in a Patient with Waldenstrom Macroglobulinemia: A Case Report

Albert B. Lin; Alan T. Sheyman; Lee M. Jampol

doi:10.1097/ICB.0000000000000540

Unusual Serous Retinal Detachment in a Patient with Waldenstrom Macroglobulinemia: A Case Report

Albert B. Lin, Alan T. Sheyman, Lee M. Jampol^*

^*Corresponding author for this work

Ophthalmology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background/Purpose: To report an unusual appearance of severe bilateral serous detachments in a patient with Waldenstrom macroglobulinemia. Methods: A case report of a Fifty-six-year-old female patient with Waldenstrom macroglobulinemia. Results: A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom. The patient's IgM levels remained abnormally elevated in the initial stages of her disease course, leading to dramatic ocular findings and images on optical coherence tomography. Chemotherapy was initiated and IgM levels slowly declined, with some improvement in macular fluid as IgM normalized. Conclusion: Waldenstrom macroglobulinemia may lead to dramatic retinal pathology if IgM levels remain elevated. Prompt chemotherapy and reduction of immunoglobulin levels should be undertaken to preserve retinal architecture.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Retinal Cases and Brief Reports
Volume	13
Issue number	1
DOIs	https://doi.org/10.1097/ICB.0000000000000540
State	Published - Dec 1 2019

Keywords

Waldenstrom macroglobulinemia
maculopathy
retinal detachment
serous macular detachment

ASJC Scopus subject areas

Ophthalmology

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10.1097/ICB.0000000000000540

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title = "Unusual Serous Retinal Detachment in a Patient with Waldenstrom Macroglobulinemia: A Case Report",

abstract = "Background/Purpose: To report an unusual appearance of severe bilateral serous detachments in a patient with Waldenstrom macroglobulinemia. Methods: A case report of a Fifty-six-year-old female patient with Waldenstrom macroglobulinemia. Results: A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom. The patient's IgM levels remained abnormally elevated in the initial stages of her disease course, leading to dramatic ocular findings and images on optical coherence tomography. Chemotherapy was initiated and IgM levels slowly declined, with some improvement in macular fluid as IgM normalized. Conclusion: Waldenstrom macroglobulinemia may lead to dramatic retinal pathology if IgM levels remain elevated. Prompt chemotherapy and reduction of immunoglobulin levels should be undertaken to preserve retinal architecture.",

keywords = "Waldenstrom macroglobulinemia, maculopathy, retinal detachment, serous macular detachment",

author = "Lin, {Albert B.} and Sheyman, {Alan T.} and Jampol, {Lee M.}",

note = "Funding Information: Supported by a grant from the Research to Prevent Blindness organization, New York City. None of the authors has any conflicting interests to disclose. Reprint requests: Lee M. Jampol, MD, Department of Ophthalmology, Northwestern University, 645 North Michigan Ave., Ste. 440, Chicago, IL 60611; e-mail: l-jampol@northwestern.edu Publisher Copyright: {\textcopyright} 2019 Lippincott Williams and Wilkins. All rights reserved.",

year = "2019",

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doi = "10.1097/ICB.0000000000000540",

language = "English (US)",

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T2 - A Case Report

AU - Lin, Albert B.

AU - Sheyman, Alan T.

AU - Jampol, Lee M.

N1 - Funding Information: Supported by a grant from the Research to Prevent Blindness organization, New York City. None of the authors has any conflicting interests to disclose. Reprint requests: Lee M. Jampol, MD, Department of Ophthalmology, Northwestern University, 645 North Michigan Ave., Ste. 440, Chicago, IL 60611; e-mail: l-jampol@northwestern.edu Publisher Copyright: © 2019 Lippincott Williams and Wilkins. All rights reserved.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Background/Purpose: To report an unusual appearance of severe bilateral serous detachments in a patient with Waldenstrom macroglobulinemia. Methods: A case report of a Fifty-six-year-old female patient with Waldenstrom macroglobulinemia. Results: A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom. The patient's IgM levels remained abnormally elevated in the initial stages of her disease course, leading to dramatic ocular findings and images on optical coherence tomography. Chemotherapy was initiated and IgM levels slowly declined, with some improvement in macular fluid as IgM normalized. Conclusion: Waldenstrom macroglobulinemia may lead to dramatic retinal pathology if IgM levels remain elevated. Prompt chemotherapy and reduction of immunoglobulin levels should be undertaken to preserve retinal architecture.

AB - Background/Purpose: To report an unusual appearance of severe bilateral serous detachments in a patient with Waldenstrom macroglobulinemia. Methods: A case report of a Fifty-six-year-old female patient with Waldenstrom macroglobulinemia. Results: A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom. The patient's IgM levels remained abnormally elevated in the initial stages of her disease course, leading to dramatic ocular findings and images on optical coherence tomography. Chemotherapy was initiated and IgM levels slowly declined, with some improvement in macular fluid as IgM normalized. Conclusion: Waldenstrom macroglobulinemia may lead to dramatic retinal pathology if IgM levels remain elevated. Prompt chemotherapy and reduction of immunoglobulin levels should be undertaken to preserve retinal architecture.

KW - Waldenstrom macroglobulinemia

KW - maculopathy

KW - retinal detachment

KW - serous macular detachment

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Unusual Serous Retinal Detachment in a Patient with Waldenstrom Macroglobulinemia: A Case Report

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