Update on fluorescence in situ hybridization in melanoma: State of the art

Pedram Gerami, Artur Zembowicz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Context.-Recent advances in understanding the molecular basis of melanoma have resulted in development of fluorescence in situ hybridization (FISH) protocols designed to detect genetic abnormalities discriminating melanoma from nevi. The most extensively studied is a 4-probe multicolor FISH probe panel targeting chromosomes 6 and 11. Validation studies showed promising sensitivity and specificity for distinguishing benign nevi and malignant melanoma by FISH. Recent studies show that a melanoma FISH assay has great potential for becoming an important diagnostic adjunct in classification of melanocyte lesions and in diagnosis of melanoma. Objective.-To present a comprehensive review of the science and practical aspects of FISH in melanoma for pathologists considering the use of melanoma FISH in their practice. Data Sources.-Review of the literature and personal experience of the authors. Conclusions.-Judicious use of a 4-probe multicolor melanoma FISH procedure can enhance accuracy for diagnosis of melanoma and improve classification of melanocytic proliferations.

Original languageEnglish (US)
Pages (from-to)830-837
Number of pages8
JournalArchives of Pathology and Laboratory Medicine
Issue number7
StatePublished - Jul 1 2011

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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