Update: The role of FoxP3 in allergic disease

Young Paik, Matthew Dahl*, Deyu Fang, Karen Calhoun

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


PURPOSE OF REVIEW: T-regulatory cells play a key role in allergic and asthmatic inflammatory airway diseases. This review discusses the importance of a critical gene associated with T-regulatory cells. Forkhead box P3 is a forkhead-winged helix transcription factor gene involved in immune function in allergy and asthma. RECENT FINDINGS: Recently, many functions of forkhead box P3 and its influence on the immune system have been elucidated. T-regulatory cells that are CD4+CD25+ and express forkhead box P3, influence the development and expression of atopy and allergic response. The exact mechanisms are not yet delineated, but multiple recent studies provide greater understanding of the mechanism of forkhead box P3 and its influence on these T-regulatory cells. SUMMARY: Greater understanding of the molecular and immunological mechanisms underlying the T-regulatory cells and forkhead box P3 will permit the development of targeted treatment modalities to influence disease processes such as allergic rhinitis and bronchial asthma.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number3
StatePublished - Jun 2008


  • Allergic rhinitis
  • Asthma
  • CD4+CD25+ T-regulatory cells
  • Forkhead box P3

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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