Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells

Joseph R. Leventhal, Joshua Miller, James M. Mathew*, Sunil Kurian, Anat R. Tambur, John Friedewald, Jane Charrette, Michael M. Abecassis

*Corresponding author for this work

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalHuman Immunology
Volume79
Issue number5
DOIs
StatePublished - May 2018

Keywords

  • Genomic markers
  • HLA-identical renal transplants
  • T and B regulatory cells
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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