Abstract
Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127−FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.
Original language | English (US) |
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Pages (from-to) | 277-282 |
Number of pages | 6 |
Journal | Human Immunology |
Volume | 79 |
Issue number | 5 |
DOIs | |
State | Published - May 2018 |
Keywords
- Genomic markers
- HLA-identical renal transplants
- T and B regulatory cells
- Tolerance
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology