TY - JOUR
T1 - Updates in Pediatric Cholestasis
AU - Kriegermeier, Alyssa
AU - Mohammad, Saeed
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/12
Y1 - 2022/12
N2 - Purpose of Review: Cholestasis is a common disorder in pediatric hepatology with a wide variety of causative etiologies. The presentation of jaundice can be frightening. Several therapies are time sensitive, and a prompt diagnosis may improve outcomes. The purpose of this paper will be to review the etiology, diagnosis, and complications of cholestasis in children and to discuss current recommendations for the management of pediatric cholestasis. Recent Findings: Medical management of pediatric cholestasis has traditionally been supportive, with care centered on nutrition, growth, and treatment of pruritus. The approval of new therapies for pruritus has changed the approach to disease management in certain diseases. Referral to a transplant center when there is advanced disease or significantly impaired quality of life remains important. Summary: There are many facets to pediatric cholestasis and attention to ameliorating the complications commonly associated with them requires subspecialized care.
AB - Purpose of Review: Cholestasis is a common disorder in pediatric hepatology with a wide variety of causative etiologies. The presentation of jaundice can be frightening. Several therapies are time sensitive, and a prompt diagnosis may improve outcomes. The purpose of this paper will be to review the etiology, diagnosis, and complications of cholestasis in children and to discuss current recommendations for the management of pediatric cholestasis. Recent Findings: Medical management of pediatric cholestasis has traditionally been supportive, with care centered on nutrition, growth, and treatment of pruritus. The approval of new therapies for pruritus has changed the approach to disease management in certain diseases. Referral to a transplant center when there is advanced disease or significantly impaired quality of life remains important. Summary: There are many facets to pediatric cholestasis and attention to ameliorating the complications commonly associated with them requires subspecialized care.
KW - Bilirubin
KW - Pediatric cholestasis
KW - Pruritus
KW - Treatment
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U2 - 10.1007/s40746-022-00257-8
DO - 10.1007/s40746-022-00257-8
M3 - Review article
AN - SCOPUS:85138684447
SN - 2198-6088
VL - 8
SP - 346
EP - 353
JO - Current Treatment Options in Pediatrics
JF - Current Treatment Options in Pediatrics
IS - 4
ER -