Updates in Pediatric Cholestasis

Alyssa Kriegermeier, Saeed Mohammad*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: Cholestasis is a common disorder in pediatric hepatology with a wide variety of causative etiologies. The presentation of jaundice can be frightening. Several therapies are time sensitive, and a prompt diagnosis may improve outcomes. The purpose of this paper will be to review the etiology, diagnosis, and complications of cholestasis in children and to discuss current recommendations for the management of pediatric cholestasis. Recent Findings: Medical management of pediatric cholestasis has traditionally been supportive, with care centered on nutrition, growth, and treatment of pruritus. The approval of new therapies for pruritus has changed the approach to disease management in certain diseases. Referral to a transplant center when there is advanced disease or significantly impaired quality of life remains important. Summary: There are many facets to pediatric cholestasis and attention to ameliorating the complications commonly associated with them requires subspecialized care.

Original languageEnglish (US)
Pages (from-to)346-353
Number of pages8
JournalCurrent Treatment Options in Pediatrics
Volume8
Issue number4
DOIs
StatePublished - Dec 2022

Keywords

  • Bilirubin
  • Pediatric cholestasis
  • Pruritus
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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