Ureaplasma Transmitted From Donor Lungs Is Pathogenic After Lung Transplantation

Ramiro Fernandez, Amy Ratliff, Donna Crabb, Ken B. Waites, Ankit Bharat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Hyperammonemia is a highly fatal syndrome in lung recipients that is usually refractory to medical therapy. We recently reported that infection by a Mollicute, Ureaplasma, is causative for hyperammonemia and can be successfully treated with antimicrobial agents. However, it remains unknown whether the pathogenic strain of Ureaplasma is donor or recipient derived. Here we provide evidence that donor-derived Ureaplasma infection can be pathogenic. As such, we uncover a previously unknown lethal donor-derived opportunistic infection in lung recipients. Given the high mortality associated with hyperammonemia, strategies for routine donor screening or prophylaxis should be further evaluated in prospective studies.

Original languageEnglish (US)
Pages (from-to)670-671
Number of pages2
JournalAnnals of Thoracic Surgery
Volume103
Issue number2
DOIs
StatePublished - Feb 1 2017

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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