Severe plasma deficiencies of clotting factors IX and XII developed in a 59 year old woman with a nephrotic syndrome secondary to a laminated membranous glomerulopathy, as verified by a renal biopsy (histopathology, electronmicroscopy). Both these clotting factors were subsequently identified in the patient's urine. Chromatographic analysis of the urine revealed that the bulk of clotting activity attributed to factors IX and XII was in early eluting gel filtration fractions containing predominantly alpha 2 globulin and albumin. The unprecedented finding of two coagulation proteins in the urine is attributed to the marked proteinuria present in this case.
ASJC Scopus subject areas
- Pathology and Forensic Medicine