Urinary Sodium in the Evaluation of Hyperchloremic Metabolic Acidosis

Daniel Batlle*, Alisa Von Riotte, William A Schlueter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

IT has long been held that systemic acidemia provides the proximate stimulus for the kidney to increase urinary acidification in response to metabolic acidosis.1 2 3 4 This view has been challenged by the experimental work of Schwartz and associates,5 6 7 8 9 which suggests that the renal acidification response to acid feeding is determined largely, not by acidemia, but by sodium delivery and sodium avidity in the distal nephron. One important implication of this provocative view is that sodium delivery to the distal nephron must be taken into account in the evaluation of normal and altered urinary acidification. Yet, the only criterion required for the…

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalNew England Journal of Medicine
Volume316
Issue number3
DOIs
StatePublished - Jan 15 1987

ASJC Scopus subject areas

  • Medicine(all)

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