TY - JOUR
T1 - Urinary Sodium in the Evaluation of Hyperchloremic Metabolic Acidosis
AU - Batlle, Daniel
AU - Von Riotte, Alisa
AU - Schlueter, William A
PY - 1987/1/15
Y1 - 1987/1/15
N2 - IT has long been held that systemic acidemia provides the proximate stimulus for the kidney to increase urinary acidification in response to metabolic acidosis.1 2 3 4 This view has been challenged by the experimental work of Schwartz and associates,5 6 7 8 9 which suggests that the renal acidification response to acid feeding is determined largely, not by acidemia, but by sodium delivery and sodium avidity in the distal nephron. One important implication of this provocative view is that sodium delivery to the distal nephron must be taken into account in the evaluation of normal and altered urinary acidification. Yet, the only criterion required for the…
AB - IT has long been held that systemic acidemia provides the proximate stimulus for the kidney to increase urinary acidification in response to metabolic acidosis.1 2 3 4 This view has been challenged by the experimental work of Schwartz and associates,5 6 7 8 9 which suggests that the renal acidification response to acid feeding is determined largely, not by acidemia, but by sodium delivery and sodium avidity in the distal nephron. One important implication of this provocative view is that sodium delivery to the distal nephron must be taken into account in the evaluation of normal and altered urinary acidification. Yet, the only criterion required for the…
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U2 - 10.1056/NEJM198701153160305
DO - 10.1056/NEJM198701153160305
M3 - Article
C2 - 3796685
AN - SCOPUS:0023110281
VL - 316
SP - 140
EP - 144
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 3
ER -