Urine protein/creatinine ratios during labor: A prospective observational study

Vaya W. Tanamai, Brandon Luke L. Seagle, Judy Y. Yeh, Bethany Brady, Corrie B. Miller, Salvador Sena, Jessica Dodge, Shohreh Shahabi, Robert Samuelson, Errol R. Norwitz, Guoyang Luo

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6 Scopus citations


Purpose: To evaluate the utility of urine protein/creatinine ratio (uPCR) measurements among healthy parturients at term we performed a prospective cohort study at a community teaching hospital. Methods: Serial urine samples were collected. Ninety-three women contributed 284 urine samples. uPCRs were determined. Multiple imputation and paired sampled analysis was performed when appropriate. Results: Two-thirds (63/93) of women had at least one measured uPCR ≥ 0.3. One-third (31/93) had a uPCR ≥ 0.3 at admission, including 39.1% (9/23) of women not in labor. Median (IQR) uPCRs increased during labor and after delivery: latent phase/no labor, 0.15 (0.06-0.32); active phase, 0.29 (0.10-0.58); early postpartum, 0.45 (0.18-1.36) (all p < 0.04). Median uPCRs were significantly < 0.3 in the latent phase and significantly > 0.3 in the immediate postpartum period (p < 0.01). Women who labored before cesarean delivery had the highest early postpartum uPCRs: median (IQR) 1.16 (0.39-1.80). A negative urine dipstick protein result did not exclude uPCR ≥ 0.3. uPCRs were similar when compared by method of urine collection. Conclusion: uPCR ≥ 0.3 is common among healthy women with uncomplicated pregnancies at term. uPCR increases during labor and is not a reliable measure of pathologic proteinuria at term or during the peripartum period.

Original languageEnglish (US)
Article numbere0160453
JournalPloS one
Issue number8
StatePublished - Aug 1 2016

ASJC Scopus subject areas

  • General


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