US valuation of health outcomes measured using the PROMIS-29

Benjamin M. Craig*, Bryce B. Reeve, Paul M. Brown, David Cella, Ron D. Hays, Joseph Lipscomb, A. Simon Pickard, Dennis A. Revicki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Objectives Health valuation studies enhance economic evaluations of treatments by estimating the value of health-related quality of life (HRQOL). The Patient-Reported Outcomes Measurement Information System (PROMIS) includes a 29-item short-form HRQOL measure, the PROMIS-29.

Methods To value PROMIS-29 responses on a quality-adjusted life-year scale, we conducted a national survey (N = 7557) using quota sampling based on the US 2010 Census. Based on 541 paired comparisons with over 350 responses each, pair-specific probabilities were incorporated into a weighted least-squared estimator.

Results All losses in HRQOL influenced choice; however, respondents valued losses in physical function, anxiety, depression, sleep, and pain more than those in fatigue and social functioning.

Conclusions This article introduces a novel approach to valuing HRQOL for economic evaluations using paired comparisons and provides a tool to translate PROMIS-29 responses into quality-adjusted life-years.

Original languageEnglish (US)
Pages (from-to)846-853
Number of pages8
JournalValue in Health
Issue number8
StatePublished - Dec 1 2014


  • discrete choice experiments
  • patient-reported outcomes
  • quality-adjusted life-years

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health Policy


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