Use of a beta-agonist in ventilated, very-low-birth-weight babies: A longitudinal evaluation

S. J. Kovacs, J. B. Fisher, N. L. Brodsky, H. Hurt

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

To determine if there is a specific postnatal (PNA) of postconceptional age (PCA) at which ventilated preterm infants respond to β-agonists, we evaluated 15 infants with a mean gestational age of 26.5 ± 1.5 weeks and mean birth weight of 0.89 ± 0.23 kg who required mechanical ventilation at 10 days of age. Weekly pulmonary function testing (PFT) was performed before and 1 h after administration of albuterol. Taking the group as a whole, as well as individual babies, regression analysis showed no relationship between positive response and either PNA or PCA. Evaluation of individual infants, however, showed that some consistently responded to β-agonists whereas others did not. We recommend individual PFT to identify those infants who will benefit from use of β-agonists.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalDevelopmental Pharmacology and Therapeutics
Volume15
Issue number2
DOIs
StatePublished - Jan 1 1990

Keywords

  • beta-agonist
  • bronchodilator
  • bronchopulmonary dysplasia
  • chronic lung disease
  • compliance
  • preterm
  • respiratory distress

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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