Use of a discrimination algorithm to reduce inappropriate shocks with a subcutaneous implantable cardioverter-defibrillator

Michael R. Gold*, Raul Weiss, Dominic A.M.J. Theuns, Warren Smith, Angel Leon, Bradley P. Knight, Nathan Carter, Michael Husby, Martin C. Burke

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Background The subcutaneous implantable cardioverter-defibrillator system (S-ICD) uses a novel detection algorithm previously shown to discriminate induced tachyarrhythmias (ventricular vs supraventricular) effectively. Objective The purpose of this study was to evaluate the role of the S-ICD discrimination algorithm in reducing the incidence of spontaneous inappropriate shocks. Methods A total of 314 subjects underwent implantation with an S-ICD system as part of the S-ICD Clinical Investigation (IDE Trial). Subjects were grouped according to programming at discharge to either a single shock zone or 2 shock zones, with a discrimination algorithm in the lower rate zone. Results This cohort had 226 subjects (72%) with dual zone programming and 88 subjects (28%) with single zone programming. Over a mean follow-up period of 661 ± 174 days, inappropriate shocks occurred in 23 subjects from the dual zone subgroup (10.2%) and 23 subjects from the single zone subgroup (26.1%, P <.001), with 2-year inappropriate shock-free rates of 89.7% vs 73.6%;,respectively (hazard ratio 0.38, P =.001). Freedom from appropriate shocks did not differ between subgroups (92.2% vs 90.3%, hazard ratio 0.82, P =.64). Moreover, mean time to appropriate therapy did not differ between subgroups, and there was only 1 episode of arrhythmic syncope in the cohort. Conclusion The addition of a second shock zone with an active discrimination algorithm was strongly associated with a reduction in inappropriate shocks with the S-ICD system and did not result in prolongation of detection times or increased syncope. These data support the use of dual zone programming as a standard setting for S-ICD patients.

Original languageEnglish (US)
Pages (from-to)1352-1358
Number of pages7
JournalHeart rhythm
Issue number8
StatePublished - Aug 2014


  • Inappropriate shock
  • Inappropriate therapy
  • Oversensing
  • Rhythm discrimination
  • Subcutaneous implantable-defibrillator
  • Supraventricular tachyarrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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