TY - JOUR
T1 - Use of a discrimination algorithm to reduce inappropriate shocks with a subcutaneous implantable cardioverter-defibrillator
AU - Gold, Michael R.
AU - Weiss, Raul
AU - Theuns, Dominic A.M.J.
AU - Smith, Warren
AU - Leon, Angel
AU - Knight, Bradley P.
AU - Carter, Nathan
AU - Husby, Michael
AU - Burke, Martin C.
PY - 2014/8
Y1 - 2014/8
N2 - Background The subcutaneous implantable cardioverter-defibrillator system (S-ICD) uses a novel detection algorithm previously shown to discriminate induced tachyarrhythmias (ventricular vs supraventricular) effectively. Objective The purpose of this study was to evaluate the role of the S-ICD discrimination algorithm in reducing the incidence of spontaneous inappropriate shocks. Methods A total of 314 subjects underwent implantation with an S-ICD system as part of the S-ICD Clinical Investigation (IDE Trial). Subjects were grouped according to programming at discharge to either a single shock zone or 2 shock zones, with a discrimination algorithm in the lower rate zone. Results This cohort had 226 subjects (72%) with dual zone programming and 88 subjects (28%) with single zone programming. Over a mean follow-up period of 661 ± 174 days, inappropriate shocks occurred in 23 subjects from the dual zone subgroup (10.2%) and 23 subjects from the single zone subgroup (26.1%, P <.001), with 2-year inappropriate shock-free rates of 89.7% vs 73.6%;,respectively (hazard ratio 0.38, P =.001). Freedom from appropriate shocks did not differ between subgroups (92.2% vs 90.3%, hazard ratio 0.82, P =.64). Moreover, mean time to appropriate therapy did not differ between subgroups, and there was only 1 episode of arrhythmic syncope in the cohort. Conclusion The addition of a second shock zone with an active discrimination algorithm was strongly associated with a reduction in inappropriate shocks with the S-ICD system and did not result in prolongation of detection times or increased syncope. These data support the use of dual zone programming as a standard setting for S-ICD patients.
AB - Background The subcutaneous implantable cardioverter-defibrillator system (S-ICD) uses a novel detection algorithm previously shown to discriminate induced tachyarrhythmias (ventricular vs supraventricular) effectively. Objective The purpose of this study was to evaluate the role of the S-ICD discrimination algorithm in reducing the incidence of spontaneous inappropriate shocks. Methods A total of 314 subjects underwent implantation with an S-ICD system as part of the S-ICD Clinical Investigation (IDE Trial). Subjects were grouped according to programming at discharge to either a single shock zone or 2 shock zones, with a discrimination algorithm in the lower rate zone. Results This cohort had 226 subjects (72%) with dual zone programming and 88 subjects (28%) with single zone programming. Over a mean follow-up period of 661 ± 174 days, inappropriate shocks occurred in 23 subjects from the dual zone subgroup (10.2%) and 23 subjects from the single zone subgroup (26.1%, P <.001), with 2-year inappropriate shock-free rates of 89.7% vs 73.6%;,respectively (hazard ratio 0.38, P =.001). Freedom from appropriate shocks did not differ between subgroups (92.2% vs 90.3%, hazard ratio 0.82, P =.64). Moreover, mean time to appropriate therapy did not differ between subgroups, and there was only 1 episode of arrhythmic syncope in the cohort. Conclusion The addition of a second shock zone with an active discrimination algorithm was strongly associated with a reduction in inappropriate shocks with the S-ICD system and did not result in prolongation of detection times or increased syncope. These data support the use of dual zone programming as a standard setting for S-ICD patients.
KW - Inappropriate shock
KW - Inappropriate therapy
KW - Oversensing
KW - Rhythm discrimination
KW - Subcutaneous implantable-defibrillator
KW - Supraventricular tachyarrhythmia
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U2 - 10.1016/j.hrthm.2014.04.012
DO - 10.1016/j.hrthm.2014.04.012
M3 - Article
C2 - 24732366
AN - SCOPUS:84904992991
VL - 11
SP - 1352
EP - 1358
JO - Heart Rhythm
JF - Heart Rhythm
SN - 1547-5271
IS - 8
ER -