Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer

Changfang Zhu, Gregory M. Palmer, Tara M. Breslin, Fushen Xu, Nirmala Ramanujam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

We explore the effects of the illumination and collection geometry on optical spectroscopic diagnosis of breast cancer. Fluorescence and diffuse reflectance spectroscopy in the UV-visible spectral range are made with a multiseparation probe at three illuminationcollection separations of 735, 980, and 1225 μm, respectively, from 13 malignant and 34 nonmalignant breast tissues. Statistical analysis is carried out on two types of data inputs: (1) the fluorescence and diffuse reflectance spectra recorded at each of the three illuminationcollection separations and (2) the integrated fluorescence (at each excitation wavelength) or diffuse reflectance over the entire spectrum at all three illumination-collection separations. The results show that using the integrated fluorescence intensities recorded at a single excitation wavelength at all three illumination-collection separations can discriminate malignant from nonmalignant breast tissues with similar classification accuracy to that using spectral data measured at several excitation wavelengths with a single illumination-collection separation. These findings have significant implications with respect to the design of an optical system for breast cancer diagnosis. Examining the intensity attenuation at a single wavelength rather than spectral intensities at multiple wavelengths can significantly reduce the measurement and data processing time in a clinical setting as well as the cost and complexity of the optical system.

Original languageEnglish (US)
Article number024032
JournalJournal of Biomedical Optics
Volume10
Issue number2
DOIs
StatePublished - Mar 2005

Keywords

  • Breast cancer
  • Fluorescence
  • Probe geometry
  • Reflectance
  • Spectroscopy

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Use of a multiseparation fiber optic probe for the optical diagnosis of breast cancer'. Together they form a unique fingerprint.

Cite this