Use of a reference tissue and blood vessel to measure the arterial input function in DCEMRI

Xiaobing Fan, Chad R. Haney, Devkumar Mustafi, Cheng Yang, Marta Zamora, Erica J. Markiewicz, Gregory S. Karczmar

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Accurate measurement of the arterial input function is critical for quantitative evaluation of dynamic contrast enhanced magnetic resonance imaging data. Use of the reference tissue method to derive a local arterial input function avoided large errors associated with direct arterial measurements, but relied on literature values for Ktrans and ve. We demonstrate that accurate values of Ktrans and ve in a reference tissue can be measured by comparing contrast media concentration in a reference tissue to plasma concentrations measured directly in a local artery after the 1-2 passes of the contrast media bolus-when plasma concentration is low and can be measured accurately. The values of Ktrans and v e calculated for the reference tissue can then be used to derive a more complete arterial input function including the first pass of the contrast bolus. This new approach was demonstrated using dynamic contrast enhanced magnetic resonance imaging data from rodent hind limb. Values obtained for Ktrans and ve in muscle, and the shape and amplitude of the derived arterial input function are consistent with published results.

Original languageEnglish (US)
Pages (from-to)1821-1826
Number of pages6
JournalMagnetic resonance in medicine
Issue number6
StatePublished - Dec 2010


  • arterial input function
  • dynamic contrast enhanced MRI
  • pharmacokinetic model
  • volume transfer constant of contrast agent

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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