Use of allogenic mesenchymal cellular bone matrix in anterior and posterior cervical spinal fusion: A case series of 21 patients

Srikanth Naga Divi*, Mark M. Mikhael

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Study Design: Retrospective case series. Purpose: To report our early experience using allogenic mesenchymal cellular bone matrix (CBM) products in cervical spine fusion. Overview of Literature: Multi-level cervical fusions have historically yielded lower fusion rates than single level fusions, especially in patients with high risk medical comorbidities. At this time, significant literature in cervical fusion outcomes with this cellular allograft technology is lacking. Methods: Twenty-one patients underwent either multilevel (3 or 4 level) anterior cervical discectomy and fusion, anterior cervical corpectomy and fusion, or posterior cervical fusion. ViviGen (DePuy Synthes Spine, Raynham, MA, USA), an allogenic bone matrix product, was used in addition to standard instrumentation. Radiographic evaluation was performed at 2 weeks, 12 weeks, 24 weeks and 1 year postoperative. Visual analog scale (VAS) and neck disability index (NDI) scores along with return to work and leisure activity were recorded. Results: At 6 months postoperative, all patients had radiographic evidence of bone fusion regardless of age or medical comorbidities. All patients reported subjective improvement with a mean decrease in VAS from 8.3 to 1.5 and a mean decrease in NDI from 40.3% to 6.0% at 1 year. All patients also returned to work and/or regular leisure activity within 3 months. Conclusions: Twenty-one patients undergoing high-risk anterior and posterior cervical spine fusion, with the use of a commercially available mesenchymal CBM product, went on to radiographic fusion and all had improvement in subjective outcomes. While further effort and research is needed to validate its widespread use, this study shows favorable use of CBM in cervical fusion for high-risk cases.

Original languageEnglish (US)
Pages (from-to)454-462
Number of pages9
JournalAsian Spine Journal
Issue number3
StatePublished - Jun 1 2017


  • Allograft
  • Bone matrix
  • Bone substitute
  • Cervical vertebrae
  • Spinal fusion

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


Dive into the research topics of 'Use of allogenic mesenchymal cellular bone matrix in anterior and posterior cervical spinal fusion: A case series of 21 patients'. Together they form a unique fingerprint.

Cite this