Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo

Christopher M. Cilip; Ashley E. Ross; Jonathan P. Jarow; Nathaniel M. Fried

doi:10.1117/12.840915

Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo

Christopher M. Cilip, Ashley E. Ross, Jonathan P. Jarow, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Development of a noninvasive vasectomy technique may eliminate male fear of complications and result in a more popular procedure. This study explores application of an optical clearing agent (OCA) to the scrotal skin to reduce both the laser power necessary for successful noninvasive laser vasectomy and the probability of scrotal skin burns. A mixture of DMSO/glycerol was noninvasively delivered into the scrotal skin using a Madajet. Near-infrared laser radiation with a range of average powers (7.0-11.7 W) was delivered in conjunction with a range of cryogen spray cooling rates (0.20-0.33 Hz) to the skin surface in a canine model, ex vivo and in vivo. Burst pressure (BP) measurements were conducted to quantify the strength of vas closure. A 30-min application of the OCA improved skin transparency by 26 ± 5 %, reducing the average power necessary for successful noninvasive laser vasectomy from 9.2 W without OCA (BP = 291 ± 31 mmHg) to 7.0 W with OCA (BP = 292 ± 19 mmHg). Control studies without OCA at 7.0 W failed to coagulate the vas with burst pressures (82 ± 28 mmHg) significantly below typical ejaculation pressures (136 ± 29 mmHg). Application of an optical clearing agent reduced the laser power necessary for successful noninvasive thermal coagulation of the vas by approximately 25%. This technique may result in the use of a less expensive laser system and eliminate the formation of scrotal skin burns during the procedure.

Original language	English (US)
Title of host publication	Photonic Therapeutics and Diagnostics VI
DOIs	https://doi.org/10.1117/12.840915
State	Published - 2010
Externally published	Yes
Event	Photonic Therapeutics and Diagnostics VI - San Francisco, CA, United States Duration: Jan 23 2010 → Jan 25 2010

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7548
ISSN (Print)	1605-7422

Other

Other	Photonic Therapeutics and Diagnostics VI
Country/Territory	United States
City	San Francisco, CA
Period	1/23/10 → 1/25/10

Keywords

incision-less
laser
male sterilization
noninvasive
optical clearing agents
vasectomy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.840915

Cite this

@inproceedings{a37e0257e92e4352bf4c6e11fec13ec7,

title = "Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo",

abstract = "Development of a noninvasive vasectomy technique may eliminate male fear of complications and result in a more popular procedure. This study explores application of an optical clearing agent (OCA) to the scrotal skin to reduce both the laser power necessary for successful noninvasive laser vasectomy and the probability of scrotal skin burns. A mixture of DMSO/glycerol was noninvasively delivered into the scrotal skin using a Madajet. Near-infrared laser radiation with a range of average powers (7.0-11.7 W) was delivered in conjunction with a range of cryogen spray cooling rates (0.20-0.33 Hz) to the skin surface in a canine model, ex vivo and in vivo. Burst pressure (BP) measurements were conducted to quantify the strength of vas closure. A 30-min application of the OCA improved skin transparency by 26 ± 5 %, reducing the average power necessary for successful noninvasive laser vasectomy from 9.2 W without OCA (BP = 291 ± 31 mmHg) to 7.0 W with OCA (BP = 292 ± 19 mmHg). Control studies without OCA at 7.0 W failed to coagulate the vas with burst pressures (82 ± 28 mmHg) significantly below typical ejaculation pressures (136 ± 29 mmHg). Application of an optical clearing agent reduced the laser power necessary for successful noninvasive thermal coagulation of the vas by approximately 25%. This technique may result in the use of a less expensive laser system and eliminate the formation of scrotal skin burns during the procedure.",

keywords = "incision-less, laser, male sterilization, noninvasive, optical clearing agents, vasectomy",

author = "Cilip, {Christopher M.} and Ross, {Ashley E.} and Jarow, {Jonathan P.} and Fried, {Nathaniel M.}",

year = "2010",

doi = "10.1117/12.840915",

language = "English (US)",

isbn = "9780819479440",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Photonic Therapeutics and Diagnostics VI",

note = "Photonic Therapeutics and Diagnostics VI ; Conference date: 23-01-2010 Through 25-01-2010",

}

Cilip, CM, Ross, AE, Jarow, JP & Fried, NM 2010, Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo. in Photonic Therapeutics and Diagnostics VI., 75481C, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7548, Photonic Therapeutics and Diagnostics VI, San Francisco, CA, United States, 1/23/10. https://doi.org/10.1117/12.840915

Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo. / Cilip, Christopher M.; Ross, Ashley E.; Jarow, Jonathan P. et al.
Photonic Therapeutics and Diagnostics VI. 2010. 75481C (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7548).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo

AU - Cilip, Christopher M.

AU - Ross, Ashley E.

AU - Jarow, Jonathan P.

AU - Fried, Nathaniel M.

PY - 2010

Y1 - 2010

N2 - Development of a noninvasive vasectomy technique may eliminate male fear of complications and result in a more popular procedure. This study explores application of an optical clearing agent (OCA) to the scrotal skin to reduce both the laser power necessary for successful noninvasive laser vasectomy and the probability of scrotal skin burns. A mixture of DMSO/glycerol was noninvasively delivered into the scrotal skin using a Madajet. Near-infrared laser radiation with a range of average powers (7.0-11.7 W) was delivered in conjunction with a range of cryogen spray cooling rates (0.20-0.33 Hz) to the skin surface in a canine model, ex vivo and in vivo. Burst pressure (BP) measurements were conducted to quantify the strength of vas closure. A 30-min application of the OCA improved skin transparency by 26 ± 5 %, reducing the average power necessary for successful noninvasive laser vasectomy from 9.2 W without OCA (BP = 291 ± 31 mmHg) to 7.0 W with OCA (BP = 292 ± 19 mmHg). Control studies without OCA at 7.0 W failed to coagulate the vas with burst pressures (82 ± 28 mmHg) significantly below typical ejaculation pressures (136 ± 29 mmHg). Application of an optical clearing agent reduced the laser power necessary for successful noninvasive thermal coagulation of the vas by approximately 25%. This technique may result in the use of a less expensive laser system and eliminate the formation of scrotal skin burns during the procedure.

AB - Development of a noninvasive vasectomy technique may eliminate male fear of complications and result in a more popular procedure. This study explores application of an optical clearing agent (OCA) to the scrotal skin to reduce both the laser power necessary for successful noninvasive laser vasectomy and the probability of scrotal skin burns. A mixture of DMSO/glycerol was noninvasively delivered into the scrotal skin using a Madajet. Near-infrared laser radiation with a range of average powers (7.0-11.7 W) was delivered in conjunction with a range of cryogen spray cooling rates (0.20-0.33 Hz) to the skin surface in a canine model, ex vivo and in vivo. Burst pressure (BP) measurements were conducted to quantify the strength of vas closure. A 30-min application of the OCA improved skin transparency by 26 ± 5 %, reducing the average power necessary for successful noninvasive laser vasectomy from 9.2 W without OCA (BP = 291 ± 31 mmHg) to 7.0 W with OCA (BP = 292 ± 19 mmHg). Control studies without OCA at 7.0 W failed to coagulate the vas with burst pressures (82 ± 28 mmHg) significantly below typical ejaculation pressures (136 ± 29 mmHg). Application of an optical clearing agent reduced the laser power necessary for successful noninvasive thermal coagulation of the vas by approximately 25%. This technique may result in the use of a less expensive laser system and eliminate the formation of scrotal skin burns during the procedure.

KW - incision-less

KW - laser

KW - male sterilization

KW - noninvasive

KW - optical clearing agents

KW - vasectomy

UR - http://www.scopus.com/inward/record.url?scp=79751497433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79751497433&partnerID=8YFLogxK

U2 - 10.1117/12.840915

DO - 10.1117/12.840915

M3 - Conference contribution

AN - SCOPUS:79751497433

SN - 9780819479440

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photonic Therapeutics and Diagnostics VI

T2 - Photonic Therapeutics and Diagnostics VI

Y2 - 23 January 2010 through 25 January 2010

ER -

Use of an optical clearing agent during noninvasive laser coagulation of the canine vas deferens, ex vivo and in vivo

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this