Use of anti-idiotypic antibodies to identify a receptor for the T-cell I-J determinant

K. Zupko, C. Waltenbaugh, B. Diamond

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13 Scopus citations


In order to identify the molecule(s) interacting with the I-J determinant on suppressor T cells, we have generated two anti-idiotypic sera: one to monoclonal anti-I-J(d) antibody and one to monoclonal anti-I-J(k) antibody. These antisera specifically block suppressor T-cell function in a genetically restricted manner and have no effect on helper T-cell activation. Both recognize a marker on primary monocytes and B cells but not on T cells. A myeloma cell line bearing this marker has been identified. Therefore, these antisera may recognize a molecule on cells interacting with suppressor T cells that is involved in mediating suppressor T-cell activity. The relationship between the T-cell I-J determinant and the molecule identified by the anti-idiotype may be similar to the relationship between the receptor on helper T cells and Ia molecules.

Original languageEnglish (US)
Pages (from-to)7399-7403
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number21
StatePublished - 1985

ASJC Scopus subject areas

  • General


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