@inproceedings{43bf4057541b448fb68d4450894799d9,
title = "Use of gold nanoshells to mediate heating induced perfusion changes in prostate tumors",
abstract = "This study investigates the potential of using gold nanoshells to mediate a thermally induced modulation of tumor vasculature in experimental prostate tumors. We demonstrate that after passive extravasation and retention of the circulating nanoshells from the tumor vasculature into the tumor interstitium, the enhanced nanoshells absorption of near-infrared irradiation over normal vasculature, can be used to increase tumor perfusion or shut it down at powers which result in no observable affects on tissue without nanoshells. Temperature rise was monitored in real time using magnetic resonance temperature imaging and registered with perfusion changes as extrapolated from MR dynamic contrast enhanced (DCE) imaging results before and after each treatment. Results indicate that nanoshell mediated heating can be used to improve perfusion and subsequently enhance drug delivery and radiation effects, or be used to shut down perfusion to assist in thermal ablative therapy delivery.",
keywords = "Contrast uptake, Gold nanoshells, MR temperature imaging, Prostate cancer, Tumor perfusion",
author = "Anil Shetty and Elliott, {Andrew M.} and Schwartz, {Jon A.} and James Wang and Emilio Esparza-Coss and Sherry Klumpp and Brian Taylor and Hazle, {John D.} and Stafford, {R. Jason}",
year = "2008",
doi = "10.1117/12.763160",
language = "English (US)",
isbn = "9780819470171",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
note = "Photonic Therapeutics and Diagnostics IV ; Conference date: 19-01-2008 Through 19-01-2008",
}
