Use of Injectable Urethral Bulking Agents in the Management of Stress Urinary Incontinence

Aisha Khalali Taylor, Elodi Dielubanza, John C Hairston*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The use of injectable bulking agents is a well-established approach to management of patients with stress urinary incontinence (SUI). No single bulking agent to date has been shown to be superior or consistently durable in the literature. Novel therapeutic strategies, including the use of injectable, muscle-derived stem cell therapy, have shown promising results in investigational stages. Urethral bulking agent therapy can be helpful in the early management of men with SUI following radical prostatectomy, and in women with SUI due to intrinsic sphincter deficiency, urethral hypermobility, or in the setting of failed midurethral sling placement. Despite their widespread use historically, biocompatible agents have been supplanted in recent years by synthetic agents secondary to their potentially improved durability and nonimmunogenic profiles.

Original languageEnglish (US)
Pages (from-to)159-166
Number of pages8
JournalCurrent Bladder Dysfunction Reports
Volume6
Issue number3
DOIs
StatePublished - Dec 1 2011

Keywords

  • Intrinsic sphincter deficiency
  • Periurethral injection
  • Stress urinary incontinence
  • Transurethral injection
  • Urethral bulking agents
  • Urinary incontinence

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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