Use of intravenous immunoglobulin and adjunctive therapies in the treatment of primary immunodeficiencies. A working group report of and study by the Primary Immunodeficiency Committee of the American Academy of Allergy Asthma and Immunology

Pierre L. Yong, John Boyle, Mark Ballow, Marcia Boyle, Melvin Berger, Jack Bleesing, Franciso A. Bonilla, Javier Chinen, Charlotte Cunninghamm-Rundles, Ramsay Fuleihan, Lois Nelson, Richard L. Wasserman, Kathleen C. Williams, Jordan S. Orange*

*Corresponding author for this work

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

There are an expanding number of primary immunodeficiency diseases (PIDDs), each associated with unique diagnostic and therapeutic complexities. Limited data, however, exist supporting specific therapeutic interventions. Thus, a survey of PIDD management was administered to allergists/immunologists in the United States to identify current perspectives and practices. Among 405 respondents, the majority of key management practices identified were consistent with existing data and guidelines, including the provision of immunoglobulin therapy, immunoglobulin dosing and selective avoidance of live viral vaccines. Practices for which there are little specific data or evidence-based guidance were also examined, including evaluation of IgG trough levels for patients receiving immunoglobulin, use of prophylactic antibiotics and recommendations for complementary/alternative medicine. Here, variability applied to PIDD patients was identified. Differences between practitioners clinically focused upon PIDD and general allergists/immunologists were also identified. Thus, a need for expanded clinical research in PIDD to optimize management and potentially improve outcomes was defined.

Original languageEnglish (US)
Pages (from-to)255-263
Number of pages9
JournalClinical Immunology
Volume135
Issue number2
DOIs
StatePublished - May 1 2010

Keywords

  • Antibiotic prophylaxis
  • Best practice
  • Complementary and alternative medicine
  • Intravenous immunoglobulin
  • Primary immunodeficiency
  • Subcutaneous immunoglobulin
  • hygiene

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Yong, P. L., Boyle, J., Ballow, M., Boyle, M., Berger, M., Bleesing, J., Bonilla, F. A., Chinen, J., Cunninghamm-Rundles, C., Fuleihan, R., Nelson, L., Wasserman, R. L., Williams, K. C., & Orange, J. S. (2010). Use of intravenous immunoglobulin and adjunctive therapies in the treatment of primary immunodeficiencies. A working group report of and study by the Primary Immunodeficiency Committee of the American Academy of Allergy Asthma and Immunology. Clinical Immunology, 135(2), 255-263. https://doi.org/10.1016/j.clim.2009.10.003