Use of Metformin for Weight Management in Children and Adolescents With Obesity in the Clinical Setting

Kathryn E. Kyler, Rachel B. Kadakia, Hannah L. Palac, Soyang Kwon, Adolfo J. Ariza, Helen J. Binns

Research output: Contribution to journalArticle

Abstract

Use of metformin for weight loss for children in a clinical setting has not been well described; therefore, we aimed to identify characteristics of obese patients prescribed metformin in a clinical setting and evaluate changes in anthropometric measures. Records of obese patients aged 10 to 18 years without diabetes attending an academic endocrinology practice from 2009 to 2013 were reviewed. Analyses assessed changes in anthropometric measures (weight, body mass index [BMI], and BMI z-score) over 12 months between those prescribed metformin (n = 49) and those not prescribed metformin (n = 142). Outcomes were standardized before using multivariable linear regression models. Patients prescribed metformin were significantly older, more often female, and had larger baseline anthropometric measures (all P < .05). In the models, subjects prescribed metformin had significantly less gain in standardized weight, BMI, and BMI z-score over 6 and 12 months (all P < .05). Metformin may be a useful weight management aid in children in a clinical setting.

Original languageEnglish (US)
Pages (from-to)1677-1685
Number of pages9
JournalClinical Pediatrics
Volume57
Issue number14
DOIs
StatePublished - Dec 1 2018

Fingerprint

Pediatric Obesity
Metformin
Weights and Measures
Body Mass Index
Linear Models
Endocrinology
Weight Loss

Keywords

  • adolescents
  • children
  • metformin
  • obesity
  • weight management

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "Use of metformin for weight loss for children in a clinical setting has not been well described; therefore, we aimed to identify characteristics of obese patients prescribed metformin in a clinical setting and evaluate changes in anthropometric measures. Records of obese patients aged 10 to 18 years without diabetes attending an academic endocrinology practice from 2009 to 2013 were reviewed. Analyses assessed changes in anthropometric measures (weight, body mass index [BMI], and BMI z-score) over 12 months between those prescribed metformin (n = 49) and those not prescribed metformin (n = 142). Outcomes were standardized before using multivariable linear regression models. Patients prescribed metformin were significantly older, more often female, and had larger baseline anthropometric measures (all P < .05). In the models, subjects prescribed metformin had significantly less gain in standardized weight, BMI, and BMI z-score over 6 and 12 months (all P < .05). Metformin may be a useful weight management aid in children in a clinical setting.",
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Use of Metformin for Weight Management in Children and Adolescents With Obesity in the Clinical Setting. / Kyler, Kathryn E.; Kadakia, Rachel B.; Palac, Hannah L.; Kwon, Soyang; Ariza, Adolfo J.; Binns, Helen J.

In: Clinical Pediatrics, Vol. 57, No. 14, 01.12.2018, p. 1677-1685.

Research output: Contribution to journalArticle

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