Use of oral anticoagulation in a real-world population with device detected atrial fibrillation

Rachel M. Kaplan, Paul D. Ziegler, Jodi Koehler, Sean Landman, Shantanu Sarkar, Rod S. Passman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


BACKGROUND: Guideline recommendations for oral anticoagulation (OAC) in patients with atrial fibrillation (AF) are based on CHA2 DS2-VASc score alone. Patients with cardiac implantable electronic devices provide an opportunity to assess how the interaction between AF duration and CHA2 DS2-VASc score influences OAC prescription rates. METHODS AND RESULTS: Data from the Optum de-identified Electronic Health Record data set were linked to the Medtronic CareLink database of cardiac implantable electronic devices. An index date was assigned as the later of 6 months after device implant or 1 year after Electronic Health Record data availability. Maximum daily AF duration (no AF, 6 minutes–23.5 hours, and >23.5 hours) was assessed for 6 months before index date. OAC prescription rates were computed as a function of both AF duration and CHA2 DS2-VASc score. A total of 35 779 patients with CHA2 DS2-VASc scores ≥1 were identified, including 27 198 not prescribed OAC. Overall OAC prescription rate among the 12 938 patients with device-detected AF >6 minutes was 36.7% and significantly higher in those with a maximum daily AF duration >23.5 hours (45.4%) compared with those with 6 minutes to 23.5 hours (28.7%). OAC prescription rates increased monotonically with both increasing AF duration and CHA2 DS2-VASc score, reaching a maximum of 67.2% for patients with AF >23.5 hours and a CHA2 DS2-VASc score ≥5. CONCLUSIONS: Real-world prescription of OAC increased with both increasing duration of AF and CHA2 DS2-VASc score. This highlights the need for further research into the role of AF duration, stroke risk, and the need for anticoagulation in patients with devices capable of long-term AF monitoring.

Original languageEnglish (US)
Article numbere018378
JournalJournal of the American Heart Association
Issue number24
StatePublished - Dec 15 2020


  • Anticoagulation
  • Atrial fibrillation
  • Device-detection
  • Subclinical

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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