Use of recombinant human bone morphogenetic protein-2 in the treatment of degenerative spondylolisthesis

Gregory D. Schroeder*, Wellington K. Hsu, Christopher K. Kepler, Mark F. Kurd, Alexander R. Vaccaro, Alpesh A. Patel, Jason W. Savage

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Study Design. A questionnaire survey. Objective. To report the current use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in lumbar fusion procedures for the treatment of degenerative spondylolisthesis (DS), and identify associated factors including fusion technique, surgeon location, surgeon specialty, or surgeon practice model. Summary of Background Data. The prevalence of rhBMP-2 use in fusions increased dramatically from 0.7% in 2002 to 24.7% in 2006, however more recent studies have identified significant complications with its use. Furthermore, an independent review of the industry-sponsored trial data has demonstrated no significant difference in fusion rates or clinical results with the use of rhBMP-2 compared with iliac-crest autograft. Methods. In July 2014, a survey was sent requesting information on the usage of rhBMP-2 in the treatment of DS. Determinants included the fusion technique, geographic location, specialty, and associated practice models. No funding was received for this work. Results. Overall, 7.8%2.0% of surgeons reported using rhBMP-2 when performing an open L4-L5 posterolateral fusion for DS; 6.2%1.8% reported using rhBMP-2 for an open L4-L5 interbody fusion, and 12.1%2.5% reported using rhBMP-2 for a L4-L5 minimally invasive (MIS) interbody fusion. The variables that were statistically associated with the use of rhBMP-2 were North America surgeons (P<0.0001) and the type of procedure (P=0.0005). Conclusion. Compared with historical data, there has been a dramatic decrease in the number of surgeons using rhBMP-2 in lumbar fusion procedures for the treatment of DS. Currently, rhBMP-2 is more commonly used by surgeons in North America and those performing MIS interbody fusions.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalSpine
Volume41
Issue number5
DOIs
StatePublished - Mar 1 2016

Keywords

  • Lumbar Spine Research Society
  • bone morphogenetic protein
  • degenerative spondylolisthesis
  • low back pain
  • lumbar fusion
  • rhBMP-2

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Use of recombinant human bone morphogenetic protein-2 in the treatment of degenerative spondylolisthesis'. Together they form a unique fingerprint.

Cite this