TY - JOUR
T1 - Use of sodium bicarbonate during pediatric cardiac admissions with cardiac arrest
T2 - Who gets it and what does it do?
AU - Loomba, Rohit S.
AU - Ahmed, Mubbasheer
AU - Abdulkarim, Mubeena
AU - Villarreal, Enrique G.
AU - Flores, Saul
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/12
Y1 - 2019/12
N2 - The objectives of this study were to characterize the use of sodium bicarbonate in pediatric cardiac admissions that experience cardiac arrest, to determine sodium bicarbonate use over the years, and to determine the impact of sodium bicarbonate on length of admissions, billed charges, and inpatient mortality. A cross-sectional study was conducted utilizing the Pediatric Health Information System database. Characteristics of admissions with and without sodium bicarbonate were initially compared by univariate analyses. The frequency by which sodium bicarbonate was used was compared by year. Regression analyses were conducted to determine the impact of sodium bicarbonate on length of stay, billed charges, and inpatient mortality. A total of 3987 (50.3%) of pediatric cardiac intensive care admissions with cardiac arrest utilized sodium bicarbonate; however, frequency changed from 62.1% in 2004 to 43.7% in 2015. Linear regression analysis demonstrated a decrease in length of stay (−27.5 days, p < 0.01) and billed charges (−$470,906, p < 0.01). Logistic regression analysis demonstrated an increase in mortality (odds ratio 1.77, 95% confidence interval 1.56–2.01). In conclusion, sodium bicarbonate is being used with less frequency over the last years in pediatric cardiac admissions with cardiac arrest. After adjustment for cardiac diagnoses, comorbidities, vasoactive medications, and other resuscitation medications, sodium bicarbonate is independently associated with increased mortality.
AB - The objectives of this study were to characterize the use of sodium bicarbonate in pediatric cardiac admissions that experience cardiac arrest, to determine sodium bicarbonate use over the years, and to determine the impact of sodium bicarbonate on length of admissions, billed charges, and inpatient mortality. A cross-sectional study was conducted utilizing the Pediatric Health Information System database. Characteristics of admissions with and without sodium bicarbonate were initially compared by univariate analyses. The frequency by which sodium bicarbonate was used was compared by year. Regression analyses were conducted to determine the impact of sodium bicarbonate on length of stay, billed charges, and inpatient mortality. A total of 3987 (50.3%) of pediatric cardiac intensive care admissions with cardiac arrest utilized sodium bicarbonate; however, frequency changed from 62.1% in 2004 to 43.7% in 2015. Linear regression analysis demonstrated a decrease in length of stay (−27.5 days, p < 0.01) and billed charges (−$470,906, p < 0.01). Logistic regression analysis demonstrated an increase in mortality (odds ratio 1.77, 95% confidence interval 1.56–2.01). In conclusion, sodium bicarbonate is being used with less frequency over the last years in pediatric cardiac admissions with cardiac arrest. After adjustment for cardiac diagnoses, comorbidities, vasoactive medications, and other resuscitation medications, sodium bicarbonate is independently associated with increased mortality.
KW - Cardiopulmonary resuscitation
KW - Congenital heart disease
KW - Heart arrest
KW - Mortality
KW - Pediatric intensive care units
KW - Pediatrics
KW - Resuscitation
KW - Sodium bicarbonate
UR - http://www.scopus.com/inward/record.url?scp=85102437301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102437301&partnerID=8YFLogxK
U2 - 10.3390/children6120136
DO - 10.3390/children6120136
M3 - Article
C2 - 31888123
AN - SCOPUS:85102437301
SN - 2227-9067
VL - 6
JO - Children
JF - Children
IS - 12
M1 - 136
ER -