Use of the QuantiFERON-TB Gold interferon-gamma release assay for screening transplant candidates: A single-center retrospective study

N. Theodoropoulos, F. Lanternier, J. Rassiwala, G. Mcnatt, L. Preczewski, E. Demayo, V. Stosor, M. G. Ison*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Background. Tuberculosis (TB) reactivation is a rare but significant complication of organ transplantation, and screening of all transplant candidates for latent infection is recommended with either an interferon-γ release assay (IGRA) or tuberculin skin test (TST). Methods. After institutional review board approval, we retrospectively collected data to describe the yield of transplant candidate screening using the QuantiFERON-TB Gold (QFT) and QuantiFERON-TB Gold In-Tube (QFT-IT) assays since the institution of TB screening in 2008 and the epidemiology of all cases of post-transplant TB in our institution since 2004. Results. A total of 2392 patients were screened with either the QFT or QFT-IT assay through October 2009; 245 (10.2%) tested positive and 206 (8.6%) were indeterminate. Of those with positive results, 107 (43.7%) were foreign born and most of the remainder had prior TB exposures. Of the tests performed at a reference lab, 29% were indeterminate, whereas 14% were indeterminate using our in-house lab. The majority of indeterminate results were seen in liver transplant candidates (40.6% vs. 11.8% in non-liver candidates). Three of 694 (0.43%) screened patients who underwent transplantation developed TB post transplant. Conclusions. Post-transplant TB occurs at a low rate with universal IGRA-based candidate screening, which is comparable to studies using TST screening.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalTransplant Infectious Disease
Volume14
Issue number1
DOIs
StatePublished - Feb 2012

Keywords

  • Candidate screening
  • Interferon-γ release assay
  • Mycobacterium tuberculosis
  • Organ transplantation
  • QuantiFERON

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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