Usefulness of serum endothelin levels in predicting death and myocardial infarction but not coronary progression in postmenopausal women with coronary disease (from the Women's Angiographic Vitamin and Estrogen [WAVE] study)

Bernice Ruo, Mark T. Tripputi, Priscilla Y. Hsue, Masahiko Saigo, Pamela Ouyang, David D. Waters*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We performed a cohort study of 392 postmenopausal women who had coronary disease to assess whether baseline serum endothelin-1 level predicts angiographic disease progression, nonfatal myocardial infarction, or death. Angiographic progression was defined as the annualized change in minimal lumen diameter of all qualifying lesions for each patient. Twenty-nine patients died or had a myocardial infarction during follow-up. Each picogram per milliliter increase in endothelin-1 was associated with a 1.8-fold increased risk of death or myocardial infarction. After adjustment for potential confounders, endothelin-1 remained a predictor of clinical events but was not correlated with angiographic progression.

Original languageEnglish (US)
Pages (from-to)335-338
Number of pages4
JournalAmerican Journal of Cardiology
Volume96
Issue number3
DOIs
StatePublished - Aug 1 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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