Usefulness of Speckle Tracking Strain Echocardiography for Assessment of Risk of Ventricular Arrhythmias After Placement of a Left Ventricular Assist Device

Ehimare Akhabue, Chan Seok Park, Sean Pinney, Anelechi Anyanwu, Farooq Chaudhry, Jagat Narula, Ajith Nair, Partho P. Sengupta*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Patients with continuous-flow left ventricular assist devices (LVADs) are at elevated risk of developing ventricular arrhythmias (VA), which can result in right ventricular dysfunction and abnormal LVAD function. Predictors of postoperative VA after LVAD placement are unclear. We hypothesized that global left ventricular circumferential strain (LVCS), a marker of transmural impairment in myocardial function, would independently predict postoperative VA in patients who underwent LVAD implantation. We studied 98 consecutive patients (57 ± 11 years, 83% men) who underwent HeartMate II axial flow LVAD placement. Speckle tracking-derived global circumferential strain was assessed from mid-left ventricular short-axis images. The primary composite end point was defined as any ventricular tachycardia that required intervention (anti-arrhythmic medication, cardioversion, implantable cardioverter defibrillator placement, implantable cardioverter defibrillator shock) or any ventricular fibrillation. A total of 33 patients (34%) experienced the primary end point (median follow-up: 7 months). Reduced LVCS was statistically significantly related to the primary end point (hazard ratio 1.77, 95% confidence interval 1.09 to 2.87 per 1 standard deviation reduction in LVCS, p = 0.02). LVCS above a cut-off value of −9.7% was associated with significantly reduced arrhythmia-free survival (log-rank p = 0.001). In conclusion, global LVCS is an independent predictor of ventricular arrhythmias after LVAD placement.

Original languageEnglish (US)
Pages (from-to)1578-1583
Number of pages6
JournalAmerican Journal of Cardiology
Volume120
Issue number9
DOIs
StatePublished - Nov 1 2017

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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