User-friendly software for the analysis of brain lesions (ABLe)

Jeffrey Solomon*, Vanessa Raymont, Allen Braun, John A. Butman, Jordan Grafman

*Corresponding author for this work

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

We previously developed a software package called ABLe (analysis of brain lesions) which characterizes brain lesions in terms of lesion volume and intersection with cytoarchitecture (e.g. Brodmann areas). Since our previous publication, there have been significant improvements to this software package which utilize methods standard to the neuroimaging community. These features include spatial normalization to the MNI template brain (standard of the international consortium for brain mapping), and use of the volume occupancy Talairach labels (VOTL) and automated anatomical labeling (AAL) atlases for full brain quantification of structures impacted by the lesion. Methods for multi-subject studies including lesion-symptom mapping proposed by Bates et al. have been extended in ABLe to produce an exploratory analysis summarizing correlations between subjects with overlapping lesions and behavioral deficit. A subset of data from an ongoing traumatic head injury study correlating deficit with brain anatomy is used to demonstrate the power of this software package.

Original languageEnglish (US)
Pages (from-to)245-254
Number of pages10
JournalComputer Methods and Programs in Biomedicine
Volume86
Issue number3
DOIs
StatePublished - Jun 2007

Keywords

  • Brain lesion
  • Brodmann areas
  • Computer software
  • Cytoarchitecture
  • Prefrontal cortex

ASJC Scopus subject areas

  • Software
  • Computer Science Applications
  • Health Informatics

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