Using imaging and genetics in zebrafish to study developing spinal circuits in vivo

David L. McLean, Joseph R. Fetcho

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations

Abstract

Imaging and molecular approaches are perfectly suited to young, transparent zebrafish (Danio rerio), where they have allowed novel functional studies of neural circuits and their links to behavior. Here, we review cutting-edge optical and genetic techniques used to dissect neural circuits in vivo and discuss their application to future studies of developing spinal circuits using living zebrafish. We anticipate that these experiments will reveal general principles governing the assembly of neural circuits that control movements.

Original languageEnglish (US)
Pages (from-to)817-834
Number of pages18
JournalDevelopmental Neurobiology
Volume68
Issue number6
DOIs
StatePublished - May 2008

Keywords

  • Danio rerio
  • Locomotion
  • Molecular
  • Neural networks
  • Optical
  • Spinal cord

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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