Using Linear Equating to Map PROMIS® Global Health Items and the PROMIS-29 V2.0 Profile Measure to the Health Utilities Index Mark 3

Ron D. Hays*, Dennis A. Revicki, David Feeny, Peter Fayers, Karen L. Spritzer, David Cella

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background: Preference-based health-related quality of life (HR-QOL) scores are useful as outcome measures in clinical studies, for monitoring the health of populations, and for estimating quality-adjusted life-years. Methods: This was a secondary analysis of data collected in an internet survey as part of the Patient-Reported Outcomes Measurement Information System (PROMIS®) project. To estimate Health Utilities Index Mark 3 (HUI-3) preference scores, we used the ten PROMIS® global health items, the PROMIS-29 V2.0 single pain intensity item and seven multi-item scales (physical functioning, fatigue, pain interference, depressive symptoms, anxiety, ability to participate in social roles and activities, sleep disturbance), and the PROMIS-29 V2.0 items. Linear regression analyses were used to identify significant predictors, followed by simple linear equating to avoid regression to the mean. Results: The regression models explained 48 % (global health items), 61 % (PROMIS-29 V2.0 scales), and 64 % (PROMIS-29 V2.0 items) of the variance in the HUI-3 preference score. Linear equated scores were similar to observed scores, although differences tended to be larger for older study participants. Conclusions: HUI-3 preference scores can be estimated from the PROMIS® global health items or PROMIS-29 V2.0. The estimated HUI-3 scores from the PROMIS® health measures can be used for economic applications and as a measure of overall HR-QOL in research.

Original languageEnglish (US)
Pages (from-to)1015-1022
Number of pages8
Issue number10
StatePublished - Oct 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Health Policy
  • Public Health, Environmental and Occupational Health

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