Using mass spectrometry to characterize self-assembled monolayers presenting peptides, proteins, and carbohydrates

Jing Su, Milan Mrksich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

149 Scopus citations

Abstract

Peptide and carbohydrate biochips can be assayed with MALDI mass spectrometry. Self-assembled monolayers (SAMs) that are modified with ligands provide a platform for identifying selective protein-ligand and enzyme-substrate interactions. MALDI provides a rapid and sensitive method for detection and avoids the need to label protein analytes with fluorescent or radioactive tags. The picture shows the mass spectrum of a SAM presenting a carbohydrate.

Original languageEnglish (US)
Pages (from-to)4715-4718
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number24
DOIs
StatePublished - Dec 16 2002

Keywords

  • Biochips
  • Carbohydrates
  • Glycosylation
  • Mass spectrometry
  • Monolayers

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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