Abstract
Peptide and carbohydrate biochips can be assayed with MALDI mass spectrometry. Self-assembled monolayers (SAMs) that are modified with ligands provide a platform for identifying selective protein-ligand and enzyme-substrate interactions. MALDI provides a rapid and sensitive method for detection and avoids the need to label protein analytes with fluorescent or radioactive tags. The picture shows the mass spectrum of a SAM presenting a carbohydrate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4715-4718 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 41 |
| Issue number | 24 |
| DOIs | |
| State | Published - Dec 16 2002 |
Keywords
- Biochips
- Carbohydrates
- Glycosylation
- Mass spectrometry
- Monolayers
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)