Using paired pulse TMS to facilitate contralateral and ipsilateral MEPs in upper extremity muscles of chronic hemiparetic stroke patients

Susan C. Schwerin*, Jun Yao, Julius P A Dewald

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In moderate to severely impaired stroke patients, single pulse TMS, with or without background facilitation, may not be able to evoke a motor response in muscles of the upper extremity, thereby hindering potential studies of stroke patients using TMS. Paired pulse TMS has been shown to facilitate responses in distal muscles of healthy subjects. In this study, our aim was to investigate thirteen muscles of the upper extremity in moderate to severely impaired stroke patients and determine the paired pulse interstimulus interval (ISI) that was optimal for facilitation of the TMS response. Methods: We recruited 8 moderate to severely impaired stroke patients and 5 healthy controls. A hotspot was found that could activate the greatest number of the 13 target upper extremity muscles. 16 ISIs were tested. Results: In healthy controls, an ISI range of 3-50. ms in the left hemisphere and 8-40. ms in the right hemisphere was optimal for activating the contralateral arm. In the stroke patients, stimulation of the non-lesioned hemisphere at an ISI of 8-50. ms was optimal for contralateral responses, similar to the control subjects, while stimulation of the lesioned hemisphere had an optimal ISI range of 12-50. ms. Ipsilateral responses in the paretic limb were frequent and the optimal ISI range was much later than the contralateral responses in stroke or controls occurring at 25-40. ms. Conclusion: In stroke and control subjects, across muscles and contralateral or ipsilateral pathways, an interstimulus interval of 25-40. ms was optimal to evoke a TMS response and resulted in the greatest degree of facilitation.

Original languageEnglish (US)
Pages (from-to)151-160
Number of pages10
JournalJournal of Neuroscience Methods
Volume195
Issue number2
DOIs
StatePublished - Feb 15 2011

Fingerprint

Upper Extremity
Stroke
Muscles
Healthy Volunteers
Arm
Extremities

Keywords

  • Facilitation
  • Interstimulus interval
  • Paired pulse
  • Stroke
  • Transcranial magnetic stimulation
  • Upper extremity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{efe323e8ac164bce84102ca2a09c0331,
title = "Using paired pulse TMS to facilitate contralateral and ipsilateral MEPs in upper extremity muscles of chronic hemiparetic stroke patients",
abstract = "In moderate to severely impaired stroke patients, single pulse TMS, with or without background facilitation, may not be able to evoke a motor response in muscles of the upper extremity, thereby hindering potential studies of stroke patients using TMS. Paired pulse TMS has been shown to facilitate responses in distal muscles of healthy subjects. In this study, our aim was to investigate thirteen muscles of the upper extremity in moderate to severely impaired stroke patients and determine the paired pulse interstimulus interval (ISI) that was optimal for facilitation of the TMS response. Methods: We recruited 8 moderate to severely impaired stroke patients and 5 healthy controls. A hotspot was found that could activate the greatest number of the 13 target upper extremity muscles. 16 ISIs were tested. Results: In healthy controls, an ISI range of 3-50. ms in the left hemisphere and 8-40. ms in the right hemisphere was optimal for activating the contralateral arm. In the stroke patients, stimulation of the non-lesioned hemisphere at an ISI of 8-50. ms was optimal for contralateral responses, similar to the control subjects, while stimulation of the lesioned hemisphere had an optimal ISI range of 12-50. ms. Ipsilateral responses in the paretic limb were frequent and the optimal ISI range was much later than the contralateral responses in stroke or controls occurring at 25-40. ms. Conclusion: In stroke and control subjects, across muscles and contralateral or ipsilateral pathways, an interstimulus interval of 25-40. ms was optimal to evoke a TMS response and resulted in the greatest degree of facilitation.",
keywords = "Facilitation, Interstimulus interval, Paired pulse, Stroke, Transcranial magnetic stimulation, Upper extremity",
author = "Schwerin, {Susan C.} and Jun Yao and Dewald, {Julius P A}",
year = "2011",
month = "2",
day = "15",
doi = "10.1016/j.jneumeth.2010.11.021",
language = "English (US)",
volume = "195",
pages = "151--160",
journal = "Journal of Neuroscience Methods",
issn = "0165-0270",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Using paired pulse TMS to facilitate contralateral and ipsilateral MEPs in upper extremity muscles of chronic hemiparetic stroke patients

AU - Schwerin, Susan C.

AU - Yao, Jun

AU - Dewald, Julius P A

PY - 2011/2/15

Y1 - 2011/2/15

N2 - In moderate to severely impaired stroke patients, single pulse TMS, with or without background facilitation, may not be able to evoke a motor response in muscles of the upper extremity, thereby hindering potential studies of stroke patients using TMS. Paired pulse TMS has been shown to facilitate responses in distal muscles of healthy subjects. In this study, our aim was to investigate thirteen muscles of the upper extremity in moderate to severely impaired stroke patients and determine the paired pulse interstimulus interval (ISI) that was optimal for facilitation of the TMS response. Methods: We recruited 8 moderate to severely impaired stroke patients and 5 healthy controls. A hotspot was found that could activate the greatest number of the 13 target upper extremity muscles. 16 ISIs were tested. Results: In healthy controls, an ISI range of 3-50. ms in the left hemisphere and 8-40. ms in the right hemisphere was optimal for activating the contralateral arm. In the stroke patients, stimulation of the non-lesioned hemisphere at an ISI of 8-50. ms was optimal for contralateral responses, similar to the control subjects, while stimulation of the lesioned hemisphere had an optimal ISI range of 12-50. ms. Ipsilateral responses in the paretic limb were frequent and the optimal ISI range was much later than the contralateral responses in stroke or controls occurring at 25-40. ms. Conclusion: In stroke and control subjects, across muscles and contralateral or ipsilateral pathways, an interstimulus interval of 25-40. ms was optimal to evoke a TMS response and resulted in the greatest degree of facilitation.

AB - In moderate to severely impaired stroke patients, single pulse TMS, with or without background facilitation, may not be able to evoke a motor response in muscles of the upper extremity, thereby hindering potential studies of stroke patients using TMS. Paired pulse TMS has been shown to facilitate responses in distal muscles of healthy subjects. In this study, our aim was to investigate thirteen muscles of the upper extremity in moderate to severely impaired stroke patients and determine the paired pulse interstimulus interval (ISI) that was optimal for facilitation of the TMS response. Methods: We recruited 8 moderate to severely impaired stroke patients and 5 healthy controls. A hotspot was found that could activate the greatest number of the 13 target upper extremity muscles. 16 ISIs were tested. Results: In healthy controls, an ISI range of 3-50. ms in the left hemisphere and 8-40. ms in the right hemisphere was optimal for activating the contralateral arm. In the stroke patients, stimulation of the non-lesioned hemisphere at an ISI of 8-50. ms was optimal for contralateral responses, similar to the control subjects, while stimulation of the lesioned hemisphere had an optimal ISI range of 12-50. ms. Ipsilateral responses in the paretic limb were frequent and the optimal ISI range was much later than the contralateral responses in stroke or controls occurring at 25-40. ms. Conclusion: In stroke and control subjects, across muscles and contralateral or ipsilateral pathways, an interstimulus interval of 25-40. ms was optimal to evoke a TMS response and resulted in the greatest degree of facilitation.

KW - Facilitation

KW - Interstimulus interval

KW - Paired pulse

KW - Stroke

KW - Transcranial magnetic stimulation

KW - Upper extremity

UR - http://www.scopus.com/inward/record.url?scp=78751705542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751705542&partnerID=8YFLogxK

U2 - 10.1016/j.jneumeth.2010.11.021

DO - 10.1016/j.jneumeth.2010.11.021

M3 - Article

C2 - 21134401

AN - SCOPUS:78751705542

VL - 195

SP - 151

EP - 160

JO - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

SN - 0165-0270

IS - 2

ER -