Using Self-Assembled Monolayers That Present Oligo(ethylene glycol) Groups to Control the Interactions of Proteins with Surfaces

Milan Mrksich*, George M. Whitesides

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

This chapter reviews the use of self-assembled monolayers of alkanethiolates on gold to control the interactions of proteins and cells with man-made materials. The work is based on the ability of monolayers that present oligo(ethylene glycol) groups to resist the non-specific adsorption of protein. The chapter describes the use of functionalized monolayers for the bio- and chemo-specific adsorption of proteins. The chapter concludes with a discussion of techniques that can pattern the formation of monolayers and that can prepare tailored substrates for the control of cell attachment.

Original languageEnglish (US)
Pages (from-to)361-373
Number of pages13
JournalACS Symposium Series
Volume680
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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