Using stimulus frequency emissions to characterize cochlear function in mice

M. A. Cheatham; E. D. Katz; K. Charaziak; P. Dallos; J. H. Siegel

doi:10.1063/1.3658115

Using stimulus frequency emissions to characterize cochlear function in mice

M. A. Cheatham^*, E. D. Katz, K. Charaziak, P. Dallos, J. H. Siegel

^*Corresponding author for this work

Communication Sciences and Disorders

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

13 Scopus citations

Abstract

Stimulus frequency otoacoustic emissions (SFOAE) were used to assay cochlear function in wildtype and prestin knockin (KI) mice. The latter contain a mutated form of the outer hair cell (OHC) motor protein (V499G/Y501H) with significantly reduced activity. Because several genetic mutations cause accelerated OHC death, it is beneficial to perform experiments in young mice without surgical intervention. Inasmuch as SFOAE thresholds are elevated by only 30 dB in KIs, it is possible to obtain SFOAE tuning functions in these animals. This approach allows sensitivity/frequency selectivity to be assayed within the basilar membane-OHC-tectorial membrane feedback loop, thereby providing information about signal processing prior to inner hair cell stimulation and auditory nerve activation.

Original language	English (US)
Title of host publication	What Fire is in Mine Ears
Subtitle of host publication	Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages	383-388
Number of pages	6
DOIs	https://doi.org/10.1063/1.3658115
State	Published - 2011
Event	11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States Duration: Jul 16 2011 → Jul 22 2011

Publication series

Name	AIP Conference Proceedings
Volume	1403
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Other

Other	11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
Country/Territory	United States
City	Williamstown, MA
Period	7/16/11 → 7/22/11

Keywords

cochlear amplifier
prestin
stimulus frequency otoacoustic emissions

ASJC Scopus subject areas

General Physics and Astronomy

Access to Document

10.1063/1.3658115

Cite this

Cheatham, M. A., Katz, E. D., Charaziak, K., Dallos, P., & Siegel, J. H. (2011). Using stimulus frequency emissions to characterize cochlear function in mice. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (pp. 383-388). (AIP Conference Proceedings; Vol. 1403). https://doi.org/10.1063/1.3658115

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title = "Using stimulus frequency emissions to characterize cochlear function in mice",

abstract = "Stimulus frequency otoacoustic emissions (SFOAE) were used to assay cochlear function in wildtype and prestin knockin (KI) mice. The latter contain a mutated form of the outer hair cell (OHC) motor protein (V499G/Y501H) with significantly reduced activity. Because several genetic mutations cause accelerated OHC death, it is beneficial to perform experiments in young mice without surgical intervention. Inasmuch as SFOAE thresholds are elevated by only 30 dB in KIs, it is possible to obtain SFOAE tuning functions in these animals. This approach allows sensitivity/frequency selectivity to be assayed within the basilar membane-OHC-tectorial membrane feedback loop, thereby providing information about signal processing prior to inner hair cell stimulation and auditory nerve activation.",

keywords = "cochlear amplifier, prestin, stimulus frequency otoacoustic emissions",

author = "Cheatham, {M. A.} and Katz, {E. D.} and K. Charaziak and P. Dallos and Siegel, {J. H.}",

year = "2011",

doi = "10.1063/1.3658115",

language = "English (US)",

isbn = "9780735409750",

series = "AIP Conference Proceedings",

pages = "383--388",

booktitle = "What Fire is in Mine Ears",

note = "11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics ; Conference date: 16-07-2011 Through 22-07-2011",

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Cheatham, MA, Katz, ED, Charaziak, K, Dallos, P & Siegel, JH 2011, Using stimulus frequency emissions to characterize cochlear function in mice. in What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. AIP Conference Proceedings, vol. 1403, pp. 383-388, 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics, Williamstown, MA, United States, 7/16/11. https://doi.org/10.1063/1.3658115

Using stimulus frequency emissions to characterize cochlear function in mice. / Cheatham, M. A.; Katz, E. D.; Charaziak, K. et al.
What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. 2011. p. 383-388 (AIP Conference Proceedings; Vol. 1403).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - Using stimulus frequency emissions to characterize cochlear function in mice

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AU - Katz, E. D.

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AU - Dallos, P.

AU - Siegel, J. H.

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N2 - Stimulus frequency otoacoustic emissions (SFOAE) were used to assay cochlear function in wildtype and prestin knockin (KI) mice. The latter contain a mutated form of the outer hair cell (OHC) motor protein (V499G/Y501H) with significantly reduced activity. Because several genetic mutations cause accelerated OHC death, it is beneficial to perform experiments in young mice without surgical intervention. Inasmuch as SFOAE thresholds are elevated by only 30 dB in KIs, it is possible to obtain SFOAE tuning functions in these animals. This approach allows sensitivity/frequency selectivity to be assayed within the basilar membane-OHC-tectorial membrane feedback loop, thereby providing information about signal processing prior to inner hair cell stimulation and auditory nerve activation.

AB - Stimulus frequency otoacoustic emissions (SFOAE) were used to assay cochlear function in wildtype and prestin knockin (KI) mice. The latter contain a mutated form of the outer hair cell (OHC) motor protein (V499G/Y501H) with significantly reduced activity. Because several genetic mutations cause accelerated OHC death, it is beneficial to perform experiments in young mice without surgical intervention. Inasmuch as SFOAE thresholds are elevated by only 30 dB in KIs, it is possible to obtain SFOAE tuning functions in these animals. This approach allows sensitivity/frequency selectivity to be assayed within the basilar membane-OHC-tectorial membrane feedback loop, thereby providing information about signal processing prior to inner hair cell stimulation and auditory nerve activation.

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KW - prestin

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Using stimulus frequency emissions to characterize cochlear function in mice

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