Using stimulus frequency emissions to characterize cochlear function in mice

Mary Ann Cheatham*, E. D. Katz, K. Charaziak, Peter Dallos, Jonathan H Siegel

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

Stimulus frequency otoacoustic emissions (SFOAE) were used to assay cochlear function in wildtype and prestin knockin (KI) mice. The latter contain a mutated form of the outer hair cell (OHC) motor protein (V499G/Y501H) with significantly reduced activity. Because several genetic mutations cause accelerated OHC death, it is beneficial to perform experiments in young mice without surgical intervention. Inasmuch as SFOAE thresholds are elevated by only 30 dB in KIs, it is possible to obtain SFOAE tuning functions in these animals. This approach allows sensitivity/frequency selectivity to be assayed within the basilar membane-OHC-tectorial membrane feedback loop, thereby providing information about signal processing prior to inner hair cell stimulation and auditory nerve activation.

Original languageEnglish (US)
Title of host publicationWhat Fire is in Mine Ears
Subtitle of host publicationProgress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages383-388
Number of pages6
Volume1403
DOIs
StatePublished - Dec 12 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: Jul 16 2011Jul 22 2011

Other

Other11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period7/16/117/22/11

Fingerprint

hair
stimuli
mice
nerves
mutations
stimulation
death
animals
signal processing
selectivity
tuning
activation
proteins
thresholds
causes
sensitivity

Keywords

  • cochlear amplifier
  • prestin
  • stimulus frequency otoacoustic emissions

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Cheatham, M. A., Katz, E. D., Charaziak, K., Dallos, P., & Siegel, J. H. (2011). Using stimulus frequency emissions to characterize cochlear function in mice. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (Vol. 1403, pp. 383-388) https://doi.org/10.1063/1.3658115
Cheatham, Mary Ann ; Katz, E. D. ; Charaziak, K. ; Dallos, Peter ; Siegel, Jonathan H. / Using stimulus frequency emissions to characterize cochlear function in mice. What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403 2011. pp. 383-388
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Cheatham, MA, Katz, ED, Charaziak, K, Dallos, P & Siegel, JH 2011, Using stimulus frequency emissions to characterize cochlear function in mice. in What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. vol. 1403, pp. 383-388, 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics, Williamstown, MA, United States, 7/16/11. https://doi.org/10.1063/1.3658115

Using stimulus frequency emissions to characterize cochlear function in mice. / Cheatham, Mary Ann; Katz, E. D.; Charaziak, K.; Dallos, Peter; Siegel, Jonathan H.

What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403 2011. p. 383-388.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Cheatham MA, Katz ED, Charaziak K, Dallos P, Siegel JH. Using stimulus frequency emissions to characterize cochlear function in mice. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. Vol. 1403. 2011. p. 383-388 https://doi.org/10.1063/1.3658115