TY - JOUR
T1 - Using the Patient-Reported Outcomes Measurement Information System (PROMIS) to measure symptom burden reported by patients with brain tumors
AU - Lai, Jin Shei
AU - Kupst, Mary Jo
AU - Beaumont, Jennifer L.
AU - Manley, Peter E.
AU - Chang, John Han Chih
AU - Hartsell, William F.
AU - Kwok, Young
AU - Fisher, Allison Piazza
AU - Goldman, Stewart
N1 - Funding Information:
This study was supported by the National Cancer Institute
Funding Information:
This study was supported by the National Cancer Institute (1R01CA174452; PI: Jin-Shei Lai). Study concept and design: Lai and Goldman. Acquisition of data: Lai, Hartsell, Chang, Manley, Kwok, Fisher, Goldman. Data analysis: Lai and Beaumont. Interpretation of analysis results: Lai, Kupst, Hartsell, Chang, Manley, Goldman. Drafting of the Manuscript: Lai. Critical revision of manuscript for important intellectual content: Kupst, Hartsell, Chang, Manley, Kwok, Fisher and Goldman. Obtained funding: Lai. Administrative, technical and material support: Lai and Goldman.
Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2019/3
Y1 - 2019/3
N2 - Background: Children with brain tumors can experience symptom burden throughout their disease continuum. The aim of the study was to evaluate symptom burden reported by children with brain tumors and factors that potentially were associated with their symptoms. Methods: Data from 199 children with brain tumors aged 7–22 (mean age = 14 years; 52% males; 76% white) were analyzed. Symptom burden was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) via computerized adaptive testing (CAT)—anxiety, depression, fatigue, mobility, upper extremity function, peer relationship, and cognition. Patients and parents completed Symptom Distress Scales (SDS). Test statistics and ANOVA were used to evaluate relationships between PROMIS measures and potentially influential variables. Results: Significant results (P < 0.01) showing impact of symptom burden included: PROMIS measures correlated with SDSs reported by patients and parents on all comparisons. Fatigue, mobility, and upper extremity function were associated with Karnofsky functional performance status, number of treatment modalities (0–3), and time since last treatment (≤1 year, >1 year). Fatigue and cognition were associated with educational program (regular classroom without an individualized education plan vs those that had an individualized education plan); mobility and upper extremity function were associated with time since last radiation. Mobility, upper extremity function, and anxiety were associated with time since last chemotherapy. Conclusions: Significant associations were found between PROMIS and SDS as well as clinical and demographic characteristics. Brief-yet-precise PROMIS CATs can be used to systematically assess symptom burden experienced by children with brain tumors.
AB - Background: Children with brain tumors can experience symptom burden throughout their disease continuum. The aim of the study was to evaluate symptom burden reported by children with brain tumors and factors that potentially were associated with their symptoms. Methods: Data from 199 children with brain tumors aged 7–22 (mean age = 14 years; 52% males; 76% white) were analyzed. Symptom burden was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) via computerized adaptive testing (CAT)—anxiety, depression, fatigue, mobility, upper extremity function, peer relationship, and cognition. Patients and parents completed Symptom Distress Scales (SDS). Test statistics and ANOVA were used to evaluate relationships between PROMIS measures and potentially influential variables. Results: Significant results (P < 0.01) showing impact of symptom burden included: PROMIS measures correlated with SDSs reported by patients and parents on all comparisons. Fatigue, mobility, and upper extremity function were associated with Karnofsky functional performance status, number of treatment modalities (0–3), and time since last treatment (≤1 year, >1 year). Fatigue and cognition were associated with educational program (regular classroom without an individualized education plan vs those that had an individualized education plan); mobility and upper extremity function were associated with time since last radiation. Mobility, upper extremity function, and anxiety were associated with time since last chemotherapy. Conclusions: Significant associations were found between PROMIS and SDS as well as clinical and demographic characteristics. Brief-yet-precise PROMIS CATs can be used to systematically assess symptom burden experienced by children with brain tumors.
KW - CAT
KW - PROMIS
KW - brain tumor
KW - children
KW - patient-centered outcomes
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U2 - 10.1002/pbc.27526
DO - 10.1002/pbc.27526
M3 - Article
C2 - 30426667
AN - SCOPUS:85056395148
SN - 1545-5009
VL - 66
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 3
M1 - e27526
ER -