USP33, a new player in lung cancer, mediates Slit-Robo signaling

Pushuai Wen; Ruirui Kong; Jianghong Liu; Li Zhu; Xiaoping Chen; Xiaofei Li; Yongzhan Nie; Kaichun Wu; Jane Y. Wu

doi:10.1007/s13238-014-0070-z

USP33, a new player in lung cancer, mediates Slit-Robo signaling

Pushuai Wen, Ruirui Kong, Jianghong Liu, Li Zhu, Xiaoping Chen, Xiaofei Li, Yongzhan Nie, Kaichun Wu, Jane Y. Wu

Neurology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker.

Original language	English (US)
Pages (from-to)	704-713
Number of pages	10
Journal	Protein & cell
Volume	5
Issue number	9
DOIs	https://doi.org/10.1007/s13238-014-0070-z
State	Published - Sep 1 2014

ASJC Scopus subject areas

Drug Discovery
Biochemistry
Biotechnology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13238-014-0070-z

Cite this

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title = "USP33, a new player in lung cancer, mediates Slit-Robo signaling",

abstract = "Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker. ",

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AU - Wen, Pushuai

AU - Kong, Ruirui

AU - Liu, Jianghong

AU - Zhu, Li

AU - Chen, Xiaoping

AU - Li, Xiaofei

AU - Nie, Yongzhan

AU - Wu, Kaichun

AU - Wu, Jane Y.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker.

AB - Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker.

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USP33, a new player in lung cancer, mediates Slit-Robo signaling

Abstract

ASJC Scopus subject areas

UN SDGs

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