Abstract
Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with overall benign clinical course. It has histologic features showing focal or diffuse nuclear atypia surrounded by usual type leiomyoma. Uterine leiomyosarcomas (LMS) are a group of rare and aggressive malignancies with limited treatment options available. The potential association between LM-BN with LMS is largely unknown. In this study, we report 2 cases of uterine smooth muscle tumor with typical histologic and molecular evidence of LM-BN, which are associated with its progression to the malignant counterpart of LMS. We summarize the detailed histologic, morphologic, and genomic characteristics of these 2 sets of cases. Our findings suggest that LMS progressing from preexisting LM-BN can be one of the tumor pathogenesis pathways in uterine leiomyosarcomas.
Original language | English (US) |
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Pages (from-to) | 552-565 |
Number of pages | 14 |
Journal | International Journal of Gynecological Pathology |
Volume | 41 |
Issue number | 6 |
DOIs | |
State | Published - Nov 1 2022 |
Funding
This work is partially supported by National Institutes of Health (R01CA254367) and Diana’s Fibroid Foundation.
Keywords
- DNA Copy number alteration
- Histology
- Leiomyoma with bizarre nuclei
- Leiomyosarcoma
- Uterus
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Pathology and Forensic Medicine