Abstract
Background: Potential deceased organ donors are screened for human immunodeficiency virus (HIV-1), hepatitis B virus (HBV), and hepatitis C virus (HCV) with serologic tests and nucleic acid tests (NATs). The results of these tests on the utilization of donors have not been directly measured. Methods: Twenty-six organ procurement organizations (OPOs) provided primary HIV, HBV, and HCV screening results and utilization information for donor referrals evaluated from 2004 to 2017. Additional information regarding donor organ utilization was obtained from the Organ Procurement and Transplantation Network database. Data were analyzed using logistic regression. Results: Test results were submitted for 38 166 potential deceased organ donors; 31 (0.1%) were HIV NAT-negative but seropositive, 5.2% were HBV core antibody-positive and NAT-negative, while 1.8% were HCV antibody-positive and NAT-negative. Organ utilization of HBV and/or HCV NAT-negative organs increased over time despite positive antibody status. Conclusions: Nucleic acid test detected infections in seronegative donors, especially for HCV. The use of NAT for deceased donor screening correlated with increased utilization of donor organs.
| Original language | English (US) |
|---|---|
| Article number | e13275 |
| Journal | Transplant Infectious Disease |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1 2020 |
Funding
This work was presented in part at the American Transplant Congress, 2018, Seattle, WA. This project was supported by a grant from the Mendez National Institute of Transplantation Foundation. We are grateful for the cooperation of the Association of Organ Procurement Organizations and the participating Organ Procurement Organizations and all the organ and tissue donors and their families for giving the gift of life and the gift of knowledge by their generous donations. Specifically, we thank Donor Network West, OneLegacy, LifeSharing, Donor Alliance, Inc, Iowa Donor Network, Gift of Hope, Kentucky Organ Donor Affiliates, New England Organ Bank, Living Legacy Foundation of Maryland, Gift of Life Michigan, LifeSource, Mid America Transplant, Mississippi Organ Recovery Agency, LifeShare of the Carolinas, Nebraska Organ Recovery System, Nevada Donor Network, Live On NY, Lifebanc, Life Connection of Ohio, LifeCenter Organ Donor Network, LifeShare Transplant Donor Services of Oklahoma, Pacific Northwest Transplant Bank, Gift of Life Donor Program, Center for Organ Recovery and Education, Mid-South Transplant Foundation, Intermountain Donor Services, and LifeCenter Northwest. We also acknowledge Julie Flahive for her assistance with statistical support.
Keywords
- HIV
- deceased organ donor
- hepatitis b virus
- hepatitis c virus
- organ utilization
- screening
ASJC Scopus subject areas
- Transplantation
- Infectious Diseases
