Utilizing intraluminal pressure differences to predict esophageal bolus flow dynamics

Sudip K. Ghosh, Peter J. Kahrilas, Nilesh Lodhia, John E. Pandolfino*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Successful esophageal emptying depends on the generation of a sustained intrabolus pressure (IBP) sufficient to overcome esophagogastric junction (EGJ) obstruction. Our aim was to develop a manometric analysis paradigm that describes the bolus driving pressure difference and the flow permissive time for esophageal bolus transit. Twenty normal subjects were studied with a 36-channel manometry assembly (1-cm spacing) during two 5- and one 10-ml barium swallows and concurrent fluoroscopy. Bolus domain pressure plots were generated by plotting bolus domain pressure (BDP) and EGJ relaxation pressure. BDP was defined as the pressure midway between the peristaltic ramp-up and the proximal margin of the EGJ. The flow permissive time was defined as the period where the BDP was ≥ EGJ relaxation pressure. The mean BDP was 11.7 ± 1.0 mmHg (SE), and the mean flow permissive time was 3.9 ± 0.4 s for 5-ml swallows in normal controls. The mean BDP difference during flow was 4.0 ± 1.0 mmHg. There was no significant difference in the fluoroscopic transit time and the flow permissive time calculated from the BDP plots (5 ml: fluoroscopy 3.4 ± 0.2 s; BDP 3.9 ± 0.4 s, P > 0.05). BDP plots provide a reliable measurement of IBP and its relationship with EGJ relaxation. The time available for flow can be readily delineated from this analysis, and the driving pressure responsible for flow can be accurately described and quantified. This may help predict abnormal bolus transit and the underlying mechanical properties of the EGJ.

Original languageEnglish (US)
Pages (from-to)G1023-G1028
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number5
StatePublished - Nov 2007


  • Esophageal emptying
  • Fluoroscopy
  • High-resolution manometry
  • Intraluminal pressure gradients

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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