UTX Mutations in Human Cancer

Lu Wang, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX, encoded by KDM6A) is a histone demethylase that targets di- and tri-methylated histone H3 lysine 27 (H3K27). UTX function has been linked to homeotic gene expression, embryonic development, and cellular reprogramming. UTX and its protein interactors within the COMPASS family, including the MLL3 and MLL4 lysine methyltransferases, are frequently mutated in multiple human cancers; however, the molecular basis of how these mutations contribute to oncogenesis remains unclear. Here, we discuss catalytic-dependent and -independent functions of UTX and its partners MLL3 and MLL4 as part of the COMPASS family during development and in oncogenesis.

Original languageEnglish (US)
Pages (from-to)168-176
Number of pages9
JournalCancer Cell
Volume35
Issue number2
DOIs
StatePublished - Feb 11 2019

Keywords

  • UTX
  • cancer
  • chromatin
  • gene expression
  • transcription

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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